AUTHOR'S PROFILE

van den Heuvel Leigh L

Publications (23)

Neurocognitive difficulties in trauma-exposed adults with metabolic syndrome: no influence of PTSD status or PTSD and metabolic syndrome comorbidity.

Journal: Discover mental health

Publication Year: 

Authors & Co-authors:  Suliman Sharain S van den Heuvel Leigh L Bröcker Erine E Seedat Soraya S

The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress.

Journal: Neuroimmunomodulation

Publication Year: 2024

Authors & Co-authors:  O'Hare Michaela A MA Swart Patricia C PC Malan-Müller Stefanie S van den Heuvel Leigh L LL Bröcker Erine E Seedat Soraya S Hemmings Sian M J SMJ

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.

Journal: Genome medicine

Publication Year: 2024

Authors & Co-authors:  Katrinli Seyma S Wani Agaz H AH Maihofer Adam X AX Ratanatharathorn Andrew A Daskalakis Nikolaos P NP Montalvo-Ortiz Janitza J Núñez-Ríos Diana L DL Zannas Anthony S AS Zhao Xiang X Aiello Allison E AE

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.

Journal: medRxiv : the preprint server for health sciences

Publication Year: 

Authors & Co-authors:  Katrinli Seyma S Wani Agaz H AH Maihofer Adam X AX Ratanatharathorn Andrew A Daskalakis Nikolaos P NP Montalvo-Ortiz Janitza J Núñez-Ríos Diana L DL Zannas Anthony S AS Zhao Xiang X Aiello Allison E AE

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

Journal: Nature genetics

Publication Year: 

Authors & Co-authors:  Nievergelt Caroline M CM Maihofer Adam X AX Atkinson Elizabeth G EG Chen Chia-Yen CY Choi Karmel W KW Coleman Jonathan R I JRI Daskalakis Nikolaos P NP Duncan Laramie E LE Polimanti Renato R Aaronson Cindy C

The Microbiome in Posttraumatic Stress Disorder and Trauma-Exposed Controls: An Exploratory Study.

Journal: Psychosomatic medicine

Publication Year: 2018

Authors & Co-authors:  Hemmings Sian M J SMJ Malan-Müller Stefanie S van den Heuvel Leigh L LL Demmitt Brittany A BA Stanislawski Maggie A MA Smith David G DG Bohr Adam D AD Stamper Christopher E CE Hyde Embriette R ER Morton James T JT

Agreement and Discrepancy on Emotional and Behavioral Problems Between Caregivers and HIV-Infected Children and Adolescents From Uganda.

Journal: Frontiers in psychiatry

Publication Year: 

Authors & Co-authors:  van den Heuvel Leigh L LL Levin Jonathan J Mpango Richard S RS Gadow Kenneth D KD Patel Vikram V Nachega Jean B JB Seedat Soraya S Kinyanda Eugene E

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Journal: Nature communications

Publication Year: 2020

Authors & Co-authors:  Nievergelt Caroline M CM Maihofer Adam X AX Klengel Torsten T Atkinson Elizabeth G EG Chen Chia-Yen CY Choi Karmel W KW Coleman Jonathan R I JRI Dalvie Shareefa S Duncan Laramie E LE Gelernter Joel J

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Journal: Molecular psychiatry

Publication Year: 2022

Authors & Co-authors:  Dennis Emily L EL Disner Seth G SG Fani Negar N Salminen Lauren E LE Logue Mark M Clarke Emily K EK Haswell Courtney C CC Averill Christopher L CL Baugh Lee A LA Bomyea Jessica J

Excess mortality associated with mental illness in people living with HIV in Cape Town, South Africa: a cohort study using linked electronic health records.

Journal: The Lancet. Global health

Publication Year: 2020

Authors & Co-authors:  Haas Andreas D AD Ruffieux Yann Y van den Heuvel Leigh Luella LL Lund Crick C Boulle Andrew A Euvrard Jonathan J Orrell Catherine C Prozesky Hans W HW Tiffin Nicki N Lovero Kathryn L KL

The prevalence of mental health problems in sub-Saharan adolescents: A systematic review.

Journal: PloS one

Publication Year: 2021

Authors & Co-authors:  Jörns-Presentati Astrid A Napp Ann-Kathrin AK Dessauvagie Anja S AS Stein Dan J DJ Jonker Deborah D Breet Elsie E Charles Weslin W Swart Renier L RL Lahti Mari M Suliman Sharain S

Childhood trauma, the stress response and metabolic syndrome: A focus on DNA methylation.

Journal: The European journal of neuroscience

Publication Year: 2022

Authors & Co-authors:  Womersley Jacqueline S JS Nothling Jani J Toikumo Sylvanus S Malan-Müller Stefanie S van den Heuvel Leigh L LL McGregor Nathaniel W NW Seedat Soraya S Hemmings Sîan M J SMJ

Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis.

Journal: Frontiers in neuroscience

Publication Year: 

Authors & Co-authors:  Sumner Jennifer A JA Maihofer Adam X AX Michopoulos Vasiliki V Rothbaum Alex O AO Almli Lynn M LM Andreassen Ole A OA Ashley-Koch Allison E AE Baker Dewleen G DG Beckham Jean C JC Bradley Bekh B

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.

Journal: Biological psychiatry

Publication Year: 2022

Authors & Co-authors:  Maihofer Adam X AX Choi Karmel W KW Coleman Jonathan R I JRI Daskalakis Nikolaos P NP Denckla Christy A CA Ketema Elizabeth E Morey Rajendra A RA Polimanti Renato R Ratanatharathorn Andrew A Torres Katy K

Exploring the relationship between the gut microbiome and mental health outcomes in a posttraumatic stress disorder cohort relative to trauma-exposed controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Publication Year: 2022

Authors & Co-authors:  Malan-Muller Stefanie S Valles-Colomer Mireia M Foxx Christine L CL Vieira-Silva Sara S van den Heuvel Leigh L LL Raes Jeroen J Seedat Soraya S Lowry Christopher A CA Hemmings Sian M J SMJ

RNA-seq analysis of gene expression profiles in posttraumatic stress disorder, Parkinson's disease and schizophrenia identifies roles for common and distinct biological pathways.

Journal: Discover mental health

Publication Year: 

Authors & Co-authors:  Hemmings Sian M J SMJ Swart Patricia P Womersely Jacqueline S JS Ovenden Ellen S ES van den Heuvel Leigh L LL McGregor Nathaniel W NW Meier Stuart S Bardien Soraya S Abrahams Shameemah S Tromp Gerard G

The effect of the COVID-19 lockdown on mental health care use in South Africa: an interrupted time-series analysis.

Journal: Epidemiology and psychiatric sciences

Publication Year: 2022

Authors & Co-authors:  Wettstein Anja A Tlali Mpho M Joska John A JA Cornell Morna M Skrivankova Veronika W VW Seedat Soraya S Mouton Johannes P JP van den Heuvel Leigh L LL Maxwell Nicola N Davies Mary-Ann MA

A network analysis investigating the associations between posttraumatic stress symptoms, markers of inflammation and metabolic syndrome.

Journal: Journal of psychiatric research

Publication Year: 2023

Authors & Co-authors:  Moodley Allegra A Womersley Jacqueline S JS Swart Patricia C PC van den Heuvel Leigh L LL Malan-Müller Stefanie S Seedat Soraya S Hemmings Sian M J SMJ

Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review.

Journal: Journal of neuroimmunology

Publication Year: 2023

Authors & Co-authors:  Rust Carlien C Malan-Muller Stefanie S van den Heuvel Leigh L LL Tonge Daniel D Seedat Soraya S Pretorius Etheresia E Hemmings Sian M J SMJ

Feasibility, acceptability and preliminary efficacy of a mental health self-management app in clinicians working during the COVID-19 pandemic: A pilot randomised controlled trial.

Journal: Psychiatry research

Publication Year: 2023

Authors & Co-authors:  Kirykowicz Katharine K Jaworski Beth B Owen Jason J Kirschbaum Clemens C Seedat Soraya S van den Heuvel Leigh Luella LL

Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians.

Journal: AIDS care

Publication Year: 2015

Authors & Co-authors:  van den Heuvel Leigh L Chishinga Nathaniel N Kinyanda Eugene E Weiss Helen H Patel Vikram V Ayles Helen H Harvey Justin J Cloete Karen J KJ Seedat Soraya S

Design and Development Process of a Youth Depression Screening m-Health Application for Primary Health Care Workers in South Africa and Zambia: An Overview of the MEGA Project.

Journal: Issues in mental health nursing

Publication Year: 2020

Authors & Co-authors:  Lahti Mari M Groen Gunter G Mwape Lonia L Korhonen Joonas J Breet Elsie E Chapima Fabian F Coetzee Marita M Ellilä Heikki H Jansen Ronelle R Jonker Deporah D

Development of a Mobile Application for Detection of Adolescent Mental Health Problems and Feasibility Assessment with Primary Health Care Workers.

Journal: Issues in mental health nursing

Publication Year: 2022

Authors & Co-authors:  Groen Gunter G Jörns-Presentati Astrid A Dessauvagie Anja A Seedat Soraya S van den Heuvel Leigh L LL Suliman Sharain S Grobler Gerhard G Jansen Ronelle R Mwape Lonia L Mukwato Patricia P