Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.
Journal: Molecular psychiatry
Volume: 26
Issue: 8
Year of Publication: 2022
Affiliated Institutions:
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA. emily.dennis@hsc.utah.edu.
Minneapolis VA Health Care System, Minneapolis, MN, USA.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Clinical Neuroscience Division, National Center for PTSD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA.
Department of Psychological Sciences, Center for Trauma Recovery University of Missouri-St. Louis, St. Louis, MO, USA.
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Health Services Research Center, University of California, San Diego, CA, USA.
Department of Psychiatry, Western University, London, ON, Canada.
Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Department of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Division of Neuroradiology, Brigham and Women's Hospital, Boston, MA, USA.
Department of Psychology, The Ohio State University, Columbus, OH, USA.
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
SA Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Brain Center Rudolf Magnus, Department of Psychiatry, UMCU, Utrecht, The Netherlands.
Brain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Laboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
University Medical Centre Charite, Berlin, Germany.
VISN Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
University of the Sunshine Coast, Birtinya, QLD, Australia.
Department of Psychology, University of Washington, Seattle, WA, USA.
South African Medical Research Council / Stellenbosch University Genomics of Brain Disorders Research Unit, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Department of Psychology and Brain Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.
Sioux Falls VA Health Care System, Sioux Falls, SD, USA.
Houston Fire Department, Houston, TX, USA.
Department of Psychiatry, LUMC, Leiden, The Netherlands.
Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Dartmouth College, Hanover, NH, USA.
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Joint Trauma System, Chambers Pass, Joint Base San Antonio, Fort Sam Houston, TX, USA.
School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Dept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Departments of Neurology and Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Department of Psychology, Harvard University, Cambridge, MA, USA.
Department of Psychiatry, Amsterdam University Medical Centers, Location VU University Medical Center, VU University, Amsterdam, The Netherlands.
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract summary
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
Authors & Co-authors:
Dennis Emily L EL
Disner Seth G SG
Fani Negar N
Salminen Lauren E LE
Logue Mark M
Clarke Emily K EK
Haswell Courtney C CC
Averill Christopher L CL
Baugh Lee A LA
Bomyea Jessica J
Bruce Steven E SE
Cha Jiook J
Choi Kyle K
Davenport Nicholas D ND
Densmore Maria M
du Plessis Stefan S
Forster Gina L GL
Frijling Jessie L JL
Gonenc Atilla A
Gruber Staci S
Grupe Daniel W DW
Guenette Jeffrey P JP
Hayes Jasmeet J
Hofmann David D
Ipser Jonathan J
Jovanovic Tanja T
Kelly Sinead S
Kennis Mitzy M
Kinzel Philipp P
Koch Saskia B J SBJ
Koerte Inga I
Koopowitz Sheri S
Korgaonkar Mayuresh M
Krystal John J
Lebois Lauren A M LAM
Li Gen G
Magnotta Vincent A VA
Manthey Antje A
May Geoff J GJ
Menefee Deleene S DS
Nawijn Laura L
Nelson Steven M SM
Neufeld Richard W J RWJ
Nitschke Jack B JB
O'Doherty Daniel D
Peverill Matthew M
Ressler Kerry J KJ
Roos Annerine A
Sheridan Margaret A MA
Sierk Anika A
Simmons Alan A
Simons Raluca M RM
Simons Jeffrey S JS
Stevens Jennifer J
Suarez-Jimenez Benjamin B
Sullivan Danielle R DR
Théberge Jean J
Tran Jana K JK
van den Heuvel Leigh L
van der Werff Steven J A SJA
van Rooij Sanne J H SJH
van Zuiden Mirjam M
Velez Carmen C
Verfaellie Mieke M
Vermeiren Robert R J M RRJM
Wade Benjamin S C BSC
Wager Tor T
Walter Henrik H
Winternitz Sherry S
Wolff Jonathan J
York Gerald G
Zhu Ye Y
Zhu Xi X
Abdallah Chadi G CG
Bryant Richard R
Daniels Judith K JK
Davidson Richard J RJ
Fercho Kelene A KA
Franz Carol C
Geuze Elbert E
Gordon Evan M EM
Kaufman Milissa L ML
Kremen William S WS
Lagopoulos Jim J
Lanius Ruth A RA
Lyons Michael J MJ
McCauley Stephen R SR
McGlinchey Regina R
McLaughlin Katie A KA
Milberg William W
Neria Yuval Y
Olff Miranda M
Seedat Soraya S
Shenton Martha M
Sponheim Scott R SR
Stein Dan J DJ
Stein Murray B MB
Straube Thomas T
Tate David F DF
van der Wee Nic J A NJA
Veltman Dick J DJ
Wang Li L
Wilde Elisabeth A EA
Thompson Paul M PM
Kochunov Peter P
Jahanshad Neda N
Morey Rajendra A RA
Study Outcome
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