Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis.
Journal: Frontiers in neuroscience
Volume: 15
Issue:
Year of Publication:
Affiliated Institutions:
Department of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
Department of Psychiatry, University of California, San Diego, San Diego, CA, United States.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.
Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, United States.
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States.
NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Duke Molecular Physiology Institute, Duke University, Durham, NC, United States.
Durham VA Health Care System, Durham, NC, United States.
Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Department of Radiology, University of California, San Diego, San Diego, CA, United States.
Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States.
School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, QLD, Australia.
National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, United States.
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, United States.
Department of Psychological & Brain Sciences, Boston University, Boston, MA, United States.
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, United States.
GRECC/TRACTS, VA Boston Healthcare System, Boston, MA, United States.
Center for Genomics and Personalised Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, QLD, Australia.
Department of Psychology, University of Washington, Seattle, WA, United States.
School of Psychology and Counseling, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.
Abstract summary
Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Health Working Group and investigated these associations across 11 studies of 72,224 trauma-exposed individuals of European ( = 70,870) and African ( = 1,354) ancestry. Genetic contributions to blood pressure were modeled via polygenic scores (PGS) for systolic blood pressure (SBP) and diastolic blood pressure (DBP) that were derived from a prior trans-ethnic blood pressure genome-wide association study (GWAS). Results of trans-ethnic meta-analyses revealed significant main effects of the PGS on blood pressure levels [SBP: β = 2.83, standard error (SE) = 0.06, < 1E-20; DBP: β = 1.32, SE = 0.04, < 1E-20]. Significant main effects of PTSD symptoms were also detected for SBP and DBP in trans-ethnic meta-analyses, though there was significant heterogeneity in these results. When including data from the largest contributing study - United Kingdom Biobank - PTSD symptoms were negatively associated with SBP levels (β = -1.46, SE = 0.44, = 9.8E-4) and positively associated with DBP levels (β = 0.70, SE = 0.26, = 8.1E-3). However, when excluding the United Kingdom Biobank cohort in trans-ethnic meta-analyses, there was a nominally significant positive association between PTSD symptoms and SBP levels (β = 2.81, SE = 1.13, = 0.01); no significant association was observed for DBP (β = 0.43, SE = 0.78, = 0.58). Blood pressure PGS did not significantly moderate the associations between PTSD symptoms and blood pressure levels in meta-analyses. Additional research is needed to better understand the extent to which PTSD is associated with high blood pressure and how genetic as well as contextual factors may play a role in influencing cardiovascular risk.
Authors & Co-authors:
Sumner Jennifer A JA
Maihofer Adam X AX
Michopoulos Vasiliki V
Rothbaum Alex O AO
Almli Lynn M LM
Andreassen Ole A OA
Ashley-Koch Allison E AE
Baker Dewleen G DG
Beckham Jean C JC
Bradley Bekh B
Breen Gerome G
Coleman Jonathan R I JRI
Dale Anders M AM
Dennis Michelle F MF
Feeny Norah C NC
Franz Carol E CE
Garrett Melanie E ME
Gillespie Charles F CF
Guffanti Guia G
Hauser Michael A MA
Hemmings Sian M J SMJ
Jovanovic Tanja T
Kimbrel Nathan A NA
Kremen William S WS
Lawford Bruce R BR
Logue Mark W MW
Lori Adriana A
Lyons Michael J MJ
Maples-Keller Jessica J
Mavissakalian Matig R MR
McGlinchey Regina E RE
Mehta Divya D
Mellor Rebecca R
Milberg William W
Miller Mark W MW
Morris Charles Phillip CP
Panizzon Matthew S MS
Ressler Kerry J KJ
Risbrough Victoria B VB
Rothbaum Barbara O BO
Roy-Byrne Peter P
Seedat Soraya S
Smith Alicia K AK
Stevens Jennifer S JS
van den Heuvel Leigh Luella LL
Voisey Joanne J
Young Ross McD RM
Zoellner Lori A LA
Nievergelt Caroline M CM
Wolf Erika J EJ
Study Outcome
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