Abstract summary 

Adverse childhood experiences (ACEs) increase risk for mental and physical health disorders in adulthood, particularly in individuals from sexual and ethnic minority groups. The effects of ACEs on health may be mediated by the immune system. The exact mechanisms by which an environmental exposure, such as childhood adversity, can affect the immune system are still unknown. The primary aim of this study was to determine whether early adversity is associated with significant changes in the expression of a predefined set of immune-related genes, known as the conserved transcriptional response to adversity (CTRA), in a diverse group (African American and Latino) of sexual minority men (SMM) ( = 259). Participants included HIV positive and negative males, with a median age of 31 years (range = 19-46 years), from the mSTUDY. Expression data from 53 CTRA genes were obtained at baseline and 12-month follow-up. Childhood adversity was measured with the 10-item ACEs questionnaire. Wilcoxon rank sum and chi-squared tests were used to assess differences in sociodemographic variables, HIV status, smoking, weekly alcohol use, and methamphetamine use between exposed (cumulative ACEs ≥ 1) and unexposed groups (cumulative ACEs = 0). As we had transcriptional data from two timepoints, linear mixed models were used to determine associations between ACEs (cumulative score, dichotomous measure (exposed/unexposed), childhood maltreatment, household dysfunction, abuse and neglect subscales) and CTRA gene expression. Exploratory subgroup analysis was conducted in younger (≤ median age) and older (> median age) participant groups. There were no statistically significant differences in sociodemographic variables and substance use between the exposed and unexposed groups. There were no significant associations between any of the ACEs variables and CTRA gene, suggesting that early adversity does not influence immune-related gene expression in a group of ethnically diverse SMM. Further studies are needed to assess the biological effects of ACEs in adulthood.The online version contains supplementary material available at 10.1007/s40653-024-00661-2.

Authors & Co-authors:  Dalvie Shareefa S Li Michael J MJ Kalmin Mariah M MM Cole Steven W SW Stein Dan J DJ Shoptaw Steven J SJ

Study Outcome 

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