Dementia in a resource-constrained sub-Saharan African setting: A comprehensive retrospective analysis of prevalence, risk factors, and management at the only neuropsychiatric facility in Northeastern Nigeria.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Volume: 21

Issue: 3

Year of Publication: 2025

Affiliated Institutions:  Department of Medical Services, Federal Neuropsychiatric Hospital, Maiduguri, Borno, Nigeria. Department of Human Anatomy, Faculty of Basic and Allied Medical Sciences, College of Medical Science, Gombe State University, Tudun Wada, Gombe, Nigeria. Department of Health Information, Federal Neuropsychiatric Hospital, Maiduguri, Borno, Nigeria. Biomedical Science Research and Training Centre Damaturu, Damaturu, Yobe, Nigeria. Department of Mental Health, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno, Nigeria. Department of Psychiatry, Yobe State Specialist Hospital, Damaturu, Yobe, Nigeria. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Department of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract summary 

Dementia prevalence is increasing in sub-Saharan Africa, potentially due to population growth and aging. Resource-constrained settings such as Northeastern Nigeria face challenges in dementia management.We assessed dementia burden and management at the Federal Neuropsychiatric Hospital Maiduguri, the only neuropsychiatric facility in Northeastern Nigeria. This retrospective analysis included patient records from 1999 to 2023 for individuals 60 year of age and older with a dementia diagnosis.Of the 1216 cases reported, Alzheimer's disease (60.5%) was the most common subtype, followed by vascular dementia (24.5%). Hypertension (41.6%) was the most frequent comorbidity. Memory loss was present in all cases, whereas behavioral symptoms like agitation presented in some cases. Treatments included cognitive enhancers (donepezil), supplements (gingko biloba), and non-drug therapies (psychoeducation).The increasing burden of dementia at this sole facility highlights the urgent need for targeted interventions and further research to understand the underlying factors contributing to dementia in this population.Dementia trends and management in a neuropsychiatric facility serving over 26 million people in Northeastern Nigeria. Alzheimer's disease accounted for 60.5% of the dementia cases reported, with hypertension as the leading comorbidity. There is an urgent need for improved diagnostic tools and health care infrastructure to address dementia in resource-constrained settings. The findings lay the foundation for developing a dementia cohort as part of the Northern Nigeria Dementia Research Group.

Authors & Co-authors:  Wakawa Ibrahim Abdu IA Musami Umar Baba UB Kwairanga Suleiman Hamidu SH Ogualili Placidus Nwankuba PN Mahmood Mohammed Yusuf MY Fugu Muhammad Abba MA Gimba Mohammed Mala MM Allamin Muktar Mohammed MM Abbas Zaharadeen Umar ZU Sunkani Muhammad Kawu MK Yaganami Zainab Bukar ZB Kadau Fatima Mustapha FM Sani Nasir Muhammad NM Danmallam Peter P Nanjul Luka L Babazau Larema L Muhammad Zaid Z Goni Baba Waru BW Machina Babagana Kundi BK Karch Celeste M CM Udeh-Momoh Chinedu C Karikari Thomas K TK Onyike Chiadi U CU Maina Mahmoud Bukar MB

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Akinyemi RO, Yaria J, Ojagbemi A, et al. Dementia in Africa: current evidence, knowledge gaps, and future directions. Alzheimers Dement. 2022;18:790‐809. doi:10.1002/ALZ.12432
Authors :  24
Identifiers
Doi : e14538
SSN : 1552-5279
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Alzheimer's disease;Northeastern Nigeria;dementia;dementia management;resource‐constrained settings;sub‐Saharan Africa;vascular dementia
Study Design
Cohort Study
Study Approach
Country of Study
Niger
Publication Country
United States