Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.

Journal: medRxiv : the preprint server for health sciences

Volume: 

Issue: 

Year of Publication: 

Affiliated Institutions:  Orygen, Parkville, VIC, Australia. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK. Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Regeneron Genetics Center, Tarrytown, NY, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany. Department of Psychiatry. Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain. Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda MD, USA. Laboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy. Institute for Translational Psychiatry, University of Münster, Münster, Germany. Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA. Clinic for Radiology, University Hospital Münster, Münster, Germany. Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. Instituto de Biomedicina de Sevilla (IBiS)/HUVR/CSIC/Universidad de Sevilla. CIBERSAM (ISCIII). Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. MOODS Team, INSERM , CESP, Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-, France. Department of Biomedical Sciences, Florida State University, Tallahassee, FL. Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France. Institute for Molecular Bioscience, the University of Queensland, St Lucia, QLD, Australia. Institut d'Imagerie Fonctionnelle Humaine, IFH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, France. Center for Neurobehavioral Genetics,Semel Institute for Neuroscience and Behavior David Geffen School of Medicine, University of California Los Angeles. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA. Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Department of Psychology, Stanford University, Stanford, CA USA. Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Psychological & Brain Sciences, Washington University in St. Louis. The University of Sydney, Sydney, Australia. Research Center for Child Mental Development, Chiba University. Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. Østfold University College Department of Education, ICT and Learning, Halden, Norway. Faculty of medicine, University Paris-Saclay & Bicetre hospital, APHP, Le Kremlin-Bicetre, France. Department of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin. Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Columbia. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom. Ballmer Institute for Children's Behavioral Health, University of Oregon. Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia. Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston. Universidade Federal de São Paulo, Brazil. MIPA, Université de Nîmes, Nimes, France. Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA. Department of Psychiatry, University of Cambridge, Cambridge, UK. Meditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Child Mind Institute, New York. Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK. Institute for Cognitive Science, University of Colorado Boulder, Boulder, CO, USA. Division of Imaging Science and Technology, Medical School, University of Dundee, Dundee UK. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town. Institut du Cerveau et de la Moelle épinière, ICM, Inserm U , CNRS UMR , Sorbonne Université, Paris, France. Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA. National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland. Ghent University, Ghent, Belgium. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

Abstract summary 

Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (=652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls; =1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls; =642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation (=714; mean age=36.3±15.3; female=66.1%), clinical controls (=1184; mean age=36.8±15.6; female=63.1%), and healthy controls (=1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen's < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.

Authors & Co-authors:  van Velzen Laura S LS Colic Lejla L Ceja Zuriel Z Dauvermann Maria R MR Villa Luca M LM Savage Hannah S HS Toenders Yara J YJ Dehestani Niousha N Zhu Alyssa H AH Campos Adrian I AI Salminen Lauren E LE Agartz Ingrid I Alexander Nina N Ayesa-Arriola Rosa R Ballard Elizabeth D ED Banaj Nerisa N Barkhau Carlotta C Başgöze Zeynep Z Bauer Jochen J Benedetti Francesco F Berger Klaus K Besteher Bianca B Brosch Katharina K Canal-Rivero Manuel M Cervenka Simon S Colle Romain R Connolly Colm G CG Corruble Emmanuelle E Courtet Philippe P Couvy-Duchesne Baptiste B Crespo-Facorro Benedicto B Cullen Kathryn R KR Dannlowski Udo U Deverdun Jeremy J Diaz-Zuluaga Ana M AM Dietze Lorielle M F LMF Evans Jennifer W JW Fani Negar N Flinkenflügel Kira K Friedman Naomi P NP Gotlib Ian H IH Groenewold Nynke A NA Grotegerd Dominik D Hajek Tomas T Hatoum Alexander S AS Hermesdorf Marco M Hickie Ian B IB Hirano Yoshiyuki Y Ho Tiffany C TC Ikemizu Yuki Y Iorfino Frank F Ipser Jonathan C JC Isobe Yuko Y Jackowski Andrea P AP Jollant Fabrice F Kircher Tilo T Klug Melissa M Koopowitz Sheri-Michelle SM Kraus Anna A Krug Axel A Le Bars Emmanuelle E Leehr Elisabeth J EJ Li Meng M Lippard Elizabeth T C ETC Lopez-Jaramillo Carlos C Maximov Ivan I II McIntosh Andrew M AM McLaughlin Katie A KA McWhinney Sean R SR Meinert Susanne S Melloni Elisa E Mitchell Philip B PB Mwangi Benson B Nenadić Igor I Nerland Stener S Olie Emilie E Ortiz-García de la Foz Victor V Pan Pedro M PM Pereira Fabricio F Piras Fabrizio F Piras Federica F Poletti Sara S Reineberg Andrew E AE Roberts Gloria G Romero-García Rafael R Sacchet Matthew D MD Salum Giovanni A GA Sandu Anca-Larisa AL Sellgren Carl M CM Shimizu Eiji E Smolker Harry R HR Soares Jair C JC Spalletta Gianfranco G Douglas Steele J J Stein Frederike F Stein Dan J DJ Straube Benjamin B Teutenberg Lea L Thomas-Odenthal Florian F Usemann Paula P Valabregue Romain R Valencia-Echeverry Johanna J Wagner Gerd G Waiter Gordon G Walter Martin M Whalley Heather C HC Wu Mon-Ju MJ Yang Tony T TT Zarate Carlos A CA Zugman Andre A Zunta-Soares Giovana B GB van Heeringen Kees K van Rooij Sanne J H SJH van der Wee Nic N van der Werff Steven S Thompson Paul M PM Blumberg Hilary P HP van Harmelen Anne-Laura AL Rentería Miguel E ME Jahanshad Neda N Schmaal Lianne L

Study Outcome 

Source Link: Visit source

Statistics
Citations :  WHO. Suicide worldwide in 2019: global health estimates. 2021. 2021.
Authors :  122
Identifiers
Doi : 2024.11.07.24316876
SSN : 
Study Population
Male,Female
Mesh Terms
Other Terms
Study Design
Longitudinal Study
Study Approach
Country of Study
Publication Country
United States