Genomics yields biological and phenotypic insights into bipolar disorder.

Journal: Nature

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Affiliated Institutions:  Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. k.s.oconnell@medisin.uio.no. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Division of Psychiatry, University College London, London, UK. Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. andMe Inc., Sunnyvale, CA, USA. Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK. Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. New York University, New York, NY, USA. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany. iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark. Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy. Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. National and Kapodistrian University of Athens, nd Department of Psychiatry, Attikon General Hospital, Athens, Greece. PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands. Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Ullevål, Oslo, Norway. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany. K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Psychiatry, University of California San Francisco, San Francisco, CA, USA. School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia. Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy. Programa SJD MIND Escoles, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain. Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Québec, Canada. Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan. Division of Psychiatry, University of Edinburgh, Edinburgh, UK. Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland. Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA. Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway. Center for Precision Psychiatry, University of Oslo, Oslo, Norway. Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA. Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. Department of Psychological Sciences, University of Missouri, Columbia, MO, USA. Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Psychological Medicine, University of Worcester, Worcester, UK. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Institute for Translational Psychiatry, University of Münster, Münster, Germany. Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland. Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany. Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia. Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan. Université Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France. Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland. Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA. ISGlobal, Barcelona, Spain. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Psychiatry, North East London NHS Foundation Trust, Ilford, UK. Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany. Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK. Department of Psychiatry and Psychotherapy, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Human and Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France. Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Biological and Chemical Sciences, University of Galway, Galway, Ireland. Department of Biomedicine, University of Basel, Basel, Switzerland. Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany. Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, The Netherlands. Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA. Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain. Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA. SAMRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland. Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. deCODE Genetics/Amgen, Reykjavik, Iceland. Neuroscience Research Australia, Sydney, New South Wales, Australia. Department of Psychiatry, Harvard Medical School, Boston, MA, USA. School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA. Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany. HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry, University of Münster, Münster, Germany. Université Paris Cité, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS-, Paris, France. Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia. University of Queensland, Brisbane, Queensland, Australia. Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. National and Kapodistrian University of Athens, st Department of Psychiatry, Eginition Hospital, Athens, Greece. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania. Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland. School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. Neuroscience Therapeutic Area, Janssen Research and Development, Titusville, NJ, USA. Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. University of Newcastle, Newcastle, New South Wales, Australia. Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands. Department of Psychiatry, University of Florida, Gainesville, FL, USA. Research Institute, Lindner Center of HOPE, Mason, OH, USA. Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway. Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. Rutgers Health, Rutgers University, Piscataway, NJ, USA. University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, Patras, Greece. Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Québec, Canada. Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, New South Wales, Australia. The School of Biomedical Sciences and Pharmacy, Faculty of Medicine, Health and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia. Department of Medicine and Surgery, Kore University of Enna, Enna, Italy. Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. Department of Psychiatry, Hospital Namsos, Namsos, Norway. Department of Psychiatry, McGill University, Montreal, Québec, Canada. Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway. Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain. Department of Psychology, Emory University, Atlanta, GA, USA. Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. ole.andreassen@medisin.uio.no.

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