Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial.
Journal: Emerging microbes & infections
Volume: 14
Issue: 1
Year of Publication: 2024
Affiliated Institutions: Infection, Antimicrobials, Modelling, Evolution (IAME), Université Sorbonne Paris Nord, Université Sorbonne Paris Cité, and Institut national de la santé et de la recherche médicale (Inserm), Paris, France. Bordeaux Population Health Research Centre, Université de Bordeaux, Inserm, and Inria, Bordeaux, France. Centre National de Formation et de Recherche en Santé Rurale (CNFRSR) de Mafèrinyah, Ministère de la Santé et de l'Hygiène Publique, Mafèrinyah, Guinea. University Clinical Research Center, University of Sciences, Technique and Technology of Bamako, Bamako, Mali. Partnership for Research on Ebola Virus in Liberia (PREVAIL), Monrovia, Liberia. London School of Hygiene & Tropical Medicine (LSHTM), London, UK. College of Medicine and Allied Health Sciences (COMAHS), University of Sierra Leone, Freetown, Sierra Leone. European Clinical Trials Platform & Development (EUCLID), Université de Bordeaux, Centre Hospitalier Universitaire Bordeaux, and Inserm, ISPED, Bordeaux, France. Centre pour le Développement des Vaccins, Ministère de la Santé et du Développement Social du Mali, Bamako, Mali. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Frederick, MD, USA. French Agency for Research on AIDS and Viral Hepatitis (ANRS), Emerging Infectious Diseases, PariSanté Campus, Paris, France. Inserm, Paris Cedex , France. Vaccine Research Institute, Faculté de Médicine, Université Paris-Est Créteil, Créteil, France. National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA Merck Sharp & Dohme Corp, Inc., Kenilworth, NJ, USA London School of Hygiene & Tropical Medicine, London, UK French Institute for Health and Medical Research (Inserm), , Paris, France Leidos Biomedical Research, Inc., Frederick, MD, , USA Univ. Bordeaux, INSERM, Institut Bergonié, CHU de Bordeaux, CIC-EC , Euclid/F-CRIN clinical trials platform, F-, Bordeaux, France College of Medicine and Allied Health Sciences (COMAHS), University of Sierra Leone, Freetown, Sierra Leone Partnership for Research on Ebola Virus in Liberia (PREVAIL), Monrovia, Liberia The Alliance for International Medical Action, Alima, B.P., Dakar, Sénégal Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, , Montpellier, France Centre National de Formation et de Recherche en Santé Rurale de Maferinyah, Maferinyah, Guinea Janssen Vaccines and Prevention BV Leiden, The Netherlands Center for Vaccine Development and Global Health, University of Maryland School of Medicine, West Baltimore Street Baltimore, MD, -, USA Integrated Research Facility at Fort Detrick (IRF-Frederick), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Fort Detrick, Frederick, MD, USA Département de Sociologie, FLSH, Université Cheikh Anta DIOP, Dakar, Sénégal University Clinical Research Center (UCRC), University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali School of Public Health, University of Minnesota, Minneapolis, MN, USA Centre pour le Développement des Vaccins, Ministère de la Santé, Bamako, Mali Liberia Institute for Biomedical Research Ethics Committee/National, Monrovia, Liberia School of Statistics, University of Minnesota, Minneapolis, MN, USA Advanced BioMedical Laboratories, L.L.C., Industrial Hwy, Cinnaminson, NJ, USA Agence Nationale de Sécurité Sanitaire, Conakry, Guinea INSP (Institut Nationale de Santé Publique), Conakry, Guinea Univ. Bordeaux, INSERM, Institut Bergonié, CHU de Bordeaux, CIC-EC , Euclid/F-CRIN clinical trials platform and U BPH Inria Sistm, F-, Bordeaux, France École de santé publique de l'Université de Montréal, Montréal, Canada National Institute of Mental Health, Bethesda, MD, USA
Abstract summary
rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols. ClinicalTrials.gov identifier: NCT02876328.Authors & Co-authors: Valayer Simon S Alexandre Marie M Prague Mélanie M Beavogui Abdoul Habib AH Doumbia Seydou S Kieh Mark M Greenwood Brian B Leigh Bailah B Poupelin Marie M Schwimmer Christine C Sow Samba O SO Berry Irina Maljkovic IM Kuhn Jens H JH Fusco Daniela D Cauwelaert Natasha Dubois ND Watson-Jones Deborah D Thiébaut Rodolphe R Lévy Yves Y Yazdanpanah Yazdan Y Richert Laura L Lhomme Edouard E Aboulhab Jamila J Aguirre-MacKenzie Michelle M Akoo Pauline P Akpa Esther E Akpata Robert R Albert Sara S Ale Boni Maxime BM Alimamy-Bangura Serry S Andong Pierre P Andrews Benetta C. BC Anoma Stephane S Atri Negin N Augier Augustin A Awuondo Ken K Ayouba Ahidjo A Badio Moses M Bagayoko Aminata A Balde Abby A Balssa Joséphine J Bangura Lamin Molecule LM Barrington Kesha K Barte de Saint Fare Eric E Baseler Beth B Bauder Ali A Bauduin Claire C Bawo Luke L Beavogui Abdoul Habib AH Belson Michael M Ben-Farhat Safaa S Bererd Marion M Bernaud Nicolas N Beyslow Teedoh T Biai Neirade N Billioux Jeanne J Billouin-Frazier Shere S Binachon Blandine B Blie Julie J Bockstal Viki V Boison Patricia P Bolay Fatorma F Boly Aliou A Bonawitz Rachael Elizabeth RE Borg Anne-Gaëlle AG Bosompem Samuel S Bozman Courtney C Brady Tyler T Browne Sarah S Bullis Ryan R Cagniard Barbara B Cahill Kelly K Cai Yingyun Y Camara Aissata Abdoulaye AA Camara Aboubacar Keira AK Camara Alseny Modet AM Campagne Antoine A Campion Cécilia C Cantan Alexandre A Cash Jennifer J Chai Siew Pin SP Chambelin Francois F Chea Michael M Chêne Geneviève G Choi Edouard E Chouinard Michelle M Chung Florence F Chung Lucy L Ciancia Séverine S Cisse Papa Ndiaga PN Cline-Cole Elfrida E Colin Céline C Coller Beth-Ann BA Conde Djélikan Siaka DS Cone Katherine K Cone Katherine K Connor Laurie L Connor Nicholas N Cooper Joseph Boye JB Couffin-Cardiergues Sandrine S Coulibaly Fatoumata F Coulibaly Mariam M Crew Page P Dabakuyo-Yonli Sandrine S Dabitao Djeneba D Damerval Thierry T Davis Bionca B Deen Gibrilla Fadlu GF Dekeyster Eline E Delfraissy Jean-François JF Delmas Christelle C Diakite Mahamadou M Diallo Alpha A Diallo Fatoumata Abdoulaye FA Diallo Mamadou Saliou MS Diarra Ayouba A Diarra Samba S Diawara Oualy O Dighero-Kemp Bonnie B Diop Samba S Diouf Waly W Dixit Saurabh S Djenabou Barry B Doepel Laurie L D’Ortenzio Eric E Doumbia Seydou S Doumbia Moussa Moise MM Douoguih Macaya M Dozier Nelson N Cauwelaert Natasha Dubois ND DuChêne Alain A Duvenhage Michael M Eckes Risa R Elliott Elizabeth E Enria Luisa L Espérou Hélène H Etienne Cécile C Eyler Allison A Fakoli Lawrence L Fallah Mosoka M Fauvel Marie-Alix MA Faye Sylvain S Fayiah John J Fleck Suzanne S Fofana Vemy V Tchos Karine Fouth KF Franklin Kokulo K Fusco Daniela D Gaddah Auguste A Gaignet Marylène M Gallagher Katherine K Gardner Julie J Gichini Harrison H Gozalbes Julia Garcia JG Grandits Greg G Gray Maima M Greenwood Brian B Grobler Nico N Gross Robin R Grue Louis L Grund Birgit B Guindo Oumar O Gupta Swati S Haidara Fadima F Hamz Benjamin B Hancox Emma E Hébert Jean-Christophe JC Hendriks Jenny J Hensley Patricia P Hensley Lisa E LE Herpin Betsey B Higgs Elisabeth E Hilton Trudi T Hneino Mickael M Höeltermann Tracey-Ann TA Holley Horace Preston HP Hoover Marie M Howard Natasha N Hughes Melissa M Ilo Dicko D Irvine Skip S Ishola David D Jato Yvonne Y Joe Madison M Johnson Melvin M Kaba Aboubacar Sidiki AS Kagan Jonathan J Kallon Kade K Kamara Michael M Kante Myriam M Katoudi Judith J Keita Cheick Mohamed CM Keita Sakoba S Keita Seykou S Kennedy Stephen B. SB Keshinro Babajide B Kiawu Hassan H Kieh Mark M Killinger Brent B Kinda Moumouni M Kirchoff Matthew M Kocher Gregory G Kodio Mamoudou M Kohn Brian B Koivogui Lamine L Kojan Richard R Koli Cece Francis CF Koli Jacques Seraphin JS Kollie David D Kopka Stacy S Koroma Bockarie B Kowuor Dickens D Kpayieli-Freeman Catherine C Kwast Liane L Lacabaratz Christine C Lacarra Boris B Lambert Laurie L Lambeth Courtney C Lancrey-javal Solange S Lane H. Clifford HC Langba Shadrach S Lawal Bolarinde B Lee Andrew Wen-Tseng AW Lee Shona S Lees Shelley S Lefevre Annabelle A Leigh Bailah B Lemarcis Frederic F Lévy Yves Y Levy-Marchal Claire C Leyssen Maarten M Lhomme Edouard E Liang Janie J Linga Mameni M Liu Ken K Lowe Brett B Lysander Julia J Mahamadou Ibrah I Maljkovic-Berry Irina I Mambiah Marvington M Manno Daniela D Marchand Jonathan J Marron Lindsay L Massaquoi Moses B.F. MB Masson Laure L Matard Charly C Mazur Steven S McCullough John J McFadyen Katherine K McLean Chelsea C Mercier Noémie N Michavila Pauline P Miller Tracey T Millimouno Niouma Pascal NP Miranda Alejandra A Mohamed Soumaya S Mooney Tom T Muamba Dally D Mulbah James J Ndamenyaa Rita Lukoo RL Neaton James J Neboua Désiré D Nelson Micki M Newell Kevin K Nguyen Vinh-kim VK Njie Yusupha Y Njoh Wissedi W Novotney-Barry Anna A Onorato Matthew M Onwuchekwa Uma U Orsega Susan S Ortega-Perez Inmaculada I Osborne Cynthia C Otieno Tuda T Oulaï Davy D Patel Sushma S Peart Danielle D Peeters Martine M Pettitt James J Peiffer-Smadja Nathan N Phillips Robert R Pierson Jerome J Piot Peter P Piziali Micheal M Pong Stéphany S Postnikova Elena E Proffitt Calvin C Quach Alexandre A Quigley Sinead S Randunu Nadeeka N Richert Laura L Rivière Priscille P Robinson Cynthia C Roy Céline C Russell Amy Falk AF Sahr Philip P Saliba Katy K Samai Mohamed M Samake Sibiry S Sandrus Jen J Sanogo Ibrahim I Sarro Yeya Sadio YS Sawadogo Serge S Sayadi Sani S Schvartz Maxime M Schwimmer Christine C Secka Fatou F Sharma Heema H Shelley Denise D Shobayo Bode B Siddiqui Sophia S Simon Jakub J Simpson Shelly S Sivahera Billy Muyisa BM Slater Karen K Smolskis Mary M Smout Elizabeth E Snowden Emily E Soutthiphong Anne-Aygline AA Sow Amadou A Sow Samba O. SO Sow Ydrissa Y Stirratt Michael M Stoop Jeroen J Subramaniam Guna G Surugue Léa L Swales Nathalie N Tamba Sienneh S Tang Chan C Tangara Cheick C Tapia Milagritos D. MD Teahton Julius J Tegli Jemee J Termote Monique M Thaurignac Guillaume G Thiebaut Rodolphe R Thompson Greg G Tierney John J Tindanbil Daniel D Tour Abdoulaye A Towalid Elvis E Traina Stacey S Traore Awa A Tyee Tijili T Vallée David D Vatrinet Renaud R Vincent Corine C Vogel Susan S Wallet Cedrick C Warren Travis T Watson-Jones Deborah D Weaver Wade W Wentworth Deborah D Wesseh Cecelia C Whitworth Hilary H Whitworth Jimmy J Wiedemann Aurelie A Willems Wouter W Wilson Barthalomew B Wolf Jayanthi J Wurie Alie A Yamadjako Delphine D Yaradouno Marcel M Yarmie Quiawiah Q Yazdanpanah Yazdan Y Yu Shuiqing S Zeggani Zara Z Zhou Huanying H
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Citations : Jacob ST, Crozier I, Fischer WA II, et al. . Ebola virus disease. Nat Rev Dis Primers. 2020 Feb 20;6(1):13. doi:10.1038/s41572-020-0147-3Authors : 368
Identifiers
Doi : 2432353SSN : 2222-1751