Negative valence in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium.

Journal: Biological psychiatry

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Affiliated Institutions:  Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands. Electronic address: n.dzinalija@amsterdamumc.nl. Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands. Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany. Columbia University Irving Medical College, Columbia University, New York, NY, U.S.A; Center for OCD and Related Disorders, New York State Psychiatric Institute. Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A. OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India; Schizophrenia Division, CAMH and Department of Psychiatry, University of Toronto. Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Madrid, Spain. Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Germany. OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India. Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands; Mental Healthcare Institue Geestelijke Gezondheidszorg (GGZ) Centraal, Amersfoort, the Netherlands. CIBIT/ICNAS-Univeristy of Coimbra, Portugal; Faculty of Medicine, Univ of Coimbra, Portugal. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; Clinical Academic Center - Braga, Braga, Portugal. Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands. CIBIT/ICNAS-Univeristy of Coimbra, Portugal. Department of Psychiatry, New York University Grossman School of Medicine, New York, NY; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY. Department of Psychiatry and Mental Health and Neuroscience Institute, Brain Behaviour Unit, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Faculty of Medicine, University of British Columbia; BC Children's Hosptial Research Institute. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Arkin Mental Health Care, Amsterdam, The Netherlands. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands. Schizophrenia Division, CAMH and Department of Psychiatry, University of Toronto; Radiology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Carrer de Feixa Llarga SN, , Barcelona, Spain. Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Madrid, Spain. Faculty of Health, School of Medicine, Deakin University, Australia; OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India; Goulburn Valley Health, Shepparton, VIC, Australia. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón de la Plana, Spain. Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands; GGZ inGeest Mental Health Care, Amsterdam, The Netherlands. Department of Clinical Psychology, Leiden University. Department of Social Psychology and Quantitative Psychology, Institut de Neurociències, University of Barcelona, Spain; Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain; CIBERSAM, Carlos III Health Institute, Madrid, Spain. Department of Psychiatry, New York University Grossman School of Medicine, New York, NY; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY; Neuroscience Institute, New York University Grossman School of MedicineDepartment of Psychiatry, Faculty of Medicine, University of British Columbia. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Levvel, Academic Center for Child and Adolescent Psychiatry and Specialized Youth Care, Amsterdam, The Netherlands. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai; Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands. Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, Germany. Amsterdam UMC, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Fudan University. Amsterdam UMC, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South AfricaDepartment of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands; SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam UMC, Compulsivity, Impulsivity and Attention, Amsterdam, The Netherlands.

Abstract summary 

Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled fMRI data of 633 individuals with OCD and 453 healthy controls from 16 studies using different negatively-valenced tasks across the ENIGMA-OCD Working-Group.Participant data were processed uniformly using HALFpipe, to extract voxelwise participant-level statistical images of one common first-level contrast: negative vs. neutral stimuli. In pre-registered analyses, parameter estimates were entered into Bayesian multilevel models to examine whole-brain and regional effects of OCD and its clinically relevant features - symptom severity, age of onset, and medication status.We provided a proof-of-concept that participant-level data can be combined across several task paradigms and observed one common task activation pattern across individuals with OCD and controls that encompasses fronto-limbic and visual areas implicated in negative valence. Compared to controls, individuals with OCD showed very strong evidence of weaker activation of the bilateral occipital cortex (P+<0.001) and adjacent visual processing regions during negative valence processing that was related to greater OCD severity, late-onset of disease and an unmedicated status. Individuals with OCD also showed stronger activation in the orbitofrontal, subgenual anterior cingulate and ventromedial prefrontal cortex (all P+<0.1) that was related to greater OCD severity and late onset.In the first mega-analysis of this kind, we replicate previous findings of stronger ventral prefrontal activation in OCD during negative valence processing and highlight the lateral occipital cortex as an important region implicated in altered negative valence processing.

Authors & Co-authors:  Dzinalija Nadza N Vriend Chris C Waller Lea L Simpson H Blair HB Ivanov Iliyan I Agarwal Sri Mahavir SM Alonso Pino P Backhausen Lea L LL Balachander Srinivas S Broekhuizen Aniek A Castelo-Branco Miguel M Costa Ana Daniela AD Cui Hailun H Denys Damiaan D Duarte Isabel Catarina IC Eng Goi Khia GK Erk Susanne S Fitzsimmons Sophie M D D SMDD Ipser Jonathan J Jaspers-Fayer Fern F de Joode Niels T NT Kim Minah M Koch Kathrin K Kwon Jun Soo JS van Leeuwen Wieke W Lochner Christine C van Marle Hein J F HJF Martinez-Zalacain Ignacio I Menchon Jose M JM Morgado Pedro P Narayanaswamy Janardhanan C JC Olivier Ian S IS Picó-Pérez Maria M Postma Tjardo S TS Rodriguez-Manrique Daniela D Roessner Veit V Rus-Oswald Oana Georgiana OG Shivakumar Venkataram V Soriano-Mas Carles C Stern Emily R ER Stewart S Evelyn SE van der Straten Anouk L AL Sun Bomin B Thomopoulos Sophia I SI Veltman Dick J DJ Vetter Nora C NC Visser Henny H Voon Valerie V Walter Henrik H van der Werf Ysbrand D YD van Wingen Guido G Stein Dan J DJ Thompson Paul M PM Veer Ilya M IM van den Heuvel Odile A OA

Study Outcome 

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Citations : 
Authors :  56
Identifiers
Doi : S0006-3223(24)01819-5
SSN : 1873-2402
Study Population
Male,Female
Mesh Terms
Other Terms
Obsessive-compulsive disorder;clinical features;disorder effects;mega-analysis;negative valence;task-based fMRI
Study Design
Study Approach
Country of Study
Publication Country
United States