Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents.
Journal: Journal of the American Academy of Child and Adolescent Psychiatry
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Affiliated Institutions: University of Ottawa, The Ottawa Hospital, Ontario, Canada; Ottawa Hospital Research Institute (OHRI) Ontario, Canada; King's College London, London, United Kingdom. University of Greenwich in London, United Kingdom. University of Southampton and NHS Trust, Southampton, United Kingdom. King's College London, London, United Kingdom; Universidad Católica in Montevideo, Uruguay. Aristotle University of Thessaloniki Greece. King's College London, London, United Kingdom; University of Barcelona, Barcelona, Spain; Karolinska Institutet in Stockholm, Sweden. Linköping University, Linköping, Sweden; University of Ioannina, Ioannina, Greece. Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium. University of Southern Denmark, Denmark. BioPsyC - Biopsychosocial Corporation, Vienna, Austria. University of California San Diego, California, United States. University of Basel, Basel, Switzerland. University of Fribourg, Fribourg, Switzerland. University of Lausanne, Lausanne, Switzerland. University of Zurich, Switzerland. Karolinska Institutet in Stockholm, Sweden; University of Navarra in Pamplona, Spain. King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom. Université Paris Cité, Paris, France; Institute de Psychiatrie et Neuroscience de Paris, Paris, France. Université Clermont Auvergne, Clermont-Ferrand, France. Institute de Psychiatrie et Neuroscience de Paris, Paris, France; Université de Paris, Paris, France. Université Paris Cité, Paris, France. Keio University in Tokyo, Tokyo, Japan. National Foundation of Mental Health of Bangladesh, Bangladesh. Charité Universitätsmedizin Berlin, Berlin, Germany. University of Milan, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. University of Padua, Padua, Italy. UOC Infanzia, Adolescenza, Famiglia e Consultori, Verona, Italy. University of Udine, Italy. GHNE, France. Medical University of Białystok, Bialystok, Poland. Kharazmi University, Tehran, Iran. Stellenbosch University, South Africa. South East Technological University in Waterford, Ireland. University of Nicosia, Nicosia, Cyprus. Universidade Federal de São Paulo, São Paulo, Brazil. An-Nan Hospital in Tainan, Taiwan; China Medical University Hospital in Taichung, Taiwan; Seoul National University College of Medicine, Seoul, Republic of Korea. Seoul National University Hospital, Seoul, Republic of Korea. Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Moscow Research Institute of Psychiatry, Moscow, Russia. National Institute of Mental Health in Klecany, Czech Republic. UTHealth in Houston, United States. AULSS Veneto Orientale, Italy. University of Ottawa, The Ottawa Hospital, Ontario, Canada; Aristotle University of Thessaloniki Greece. University of Modena and Reggio Emilia in Modena, Italy. ASL Salerno and the European Biomedical Research Institute of Salerno (EBRIS) in Salerno, Italy. University of Padova, Padova, Italy. University of Palermo, Palermo, Italy. University of Ottawa, The Ottawa Hospital, Ontario, Canada; University of Greenwich in London, United Kingdom. South London and Maudsley NHS Foundation Trust, London, United Kingdom. Azienda Ospedaliero-Universitaria Ss. South London and Maudsley NHS Foundation Trust, London, United Kingdom; University of Pavia, Pavia, Italy. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. Technische Universität Dresden, Dresden, Germany. Heidelberg University, Germany. Hannover Medical School, Germany. University of Freiburg, Freiburg, Germany. Ludwig-Maximilians-University of Munich, Munich, Germany. University of Lübeck, Lübeck, Germany; Semmelweis University, Budapest, Hungary. University of Ioannina, Ioannina, Greece. King's College London, London, United Kingdom. Eotvos Lorand University, Budapest, Hungary. University of Ottawa, The Ottawa Hospital, Ontario, Canada; University of Southampton and NHS Trust, Southampton, United Kingdom. Bjørknes University College, Oslo, Norway. Chulalongkorn University, Thailand; Universidade de São Paulo, São Paulo, Brazil; Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Universidad Autónoma de Chile, Providencia, Chile. Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. University of Ottawa, The Ottawa Hospital, Ontario, Canada; University of Basel, Basel, Switzerland. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Psykiatrifonden, Copenhagen, Denmark. University of Copenhagen, Copenhagen, Denmark. Le Jolimont Psychiatry and Psychotherapy, Fribourg, Switzerland. Association for the Improvement of Mental Health Programmes (AMH), Switzerland. FHNW University of Applied Sciences and Arts Northwestern Switzerland, Switzerland; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA. Universitat Autònoma de Barcelona, Barcelona, Spain. University of Texas Health Science Center, Houston, United States; Zucker Hillside Hospital, Northwell Health, and the Feinstein Institutes for Medical Research, New York. S Consulting LLC. Parc Sanitari Sant Joan de Déu, Barcelona, Spain. University of Barcelona, Barcelona, Spain. Hospital General Universitario Gregorio Marañón, Madrid, Spain. University of Barcelona, Barcelona, Spain; Mental Health Center of Perugia, Italy. Glasgow University, Glasgow, United Kingdom. Pomeranian Medical University in Szczecin, Szczecin, Poland; Sanprobi Sp. z o.o. Sp. k, Poland. Pomeranian Medical University in Szczecin, Szczecin, Poland. University of Białystok, Białystok, Poland. University of Ottawa, The Ottawa Hospital, Ontario, Canada; University of Ioannina, Ioannina, Greece. Pomeranian Medical University in Szczecin, Szczecin, Poland; Centre for Digestive Diseases Endoklinika, Szczecin, Poland. University of Ottawa, The Ottawa Hospital, Ontario, Canada; University of Southern Denmark, Denmark. University of Manchester, United Kingdom. University of Bristol, Bristol, United Kingdom. Istanbul Topkapı University, Istanbul, Turkey. Adnan Menderes University Department of Child and Adolescent Psychiatry, Aydın, Turkey. Uskudar University, Istanbul, Turkey. Universidad Católica in Montevideo, Uruguay. Griffith University, South East Queensland, Australia. Mindgardens Neuroscience Network, Sydney, Australia. Deakin University, Victoria, Australia. UNSW Sydney, Sydney, Australia. University of Medicine and Pharmacy Grigore T. Popa, Iasi, Romania. Institute of Psychiatry "Socola", Iasi, Romania. Transilvania University of Brasov, Brasov, Romania. Emergency Hospital "Nicolae Oblu", Iasi, Romania. University of Medicine and Pharmacy "Carol Davila" Bucharest, Bucharest, Romania. AmsterdamUniversity Medical Centers, Amsterdam, Netherlands. University Medical Center Groningen, Groningen, Netherlands. Utrecht University Medical Centre, Utrecht, Netherlands. Maastricht University, Maastricht, Netherlands. Carilion Clinic Virginia Tech Carilion School of Medicine, Roanoke, VA, USA. Ludwig-Maximilians-University of Munich, Munich, Germany; China Medical University Beigang Hospital, Taiwan. Shenzhen University, Shenzhen, China. Peking University Institute of Mental Health, Pekin, China. UCLouvain, Brussels, Belgium; Cliniques Universitaires Saint-Luc, Brussels, Belgium. Asociación Psiquiátrica Mexicana, Mexico. University of Minho, Braga/Guimarães, Portugal; ICVS/B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Lisbon's Psychiatric Hospital Centre, Portugal. Belarusian Medical Academy of Postgraduate Education, Belarus. Clienia AG, Switzerland. Integrated Psychiatry Winterthur (IPW), Switzerland. Kyambogo University, Kampala, Uganda. Universitäre Psychiatrische Kliniken Basel (UPK), Basel, Switzerland; Stanford University, California, USA. Mashhad University of Medical Sciences, Mashhad, Iran. Kermanshah University of Medical Sciences, Kermanshah, Iran. University of Basel, Basel, Switzerland; Kermanshah University of Medical Sciences, Kermanshah, Iran; Psychiatric Clinics of the University of Basel, Basel Switzerland; Tehran University of Medical Sciences, Tehran, Iran. Pontificia Universidad Católica de Chile, Santiago, Chile. University of Kragujevac, Kragujevac, Serbia. University of Antioquia, Medellín, Colombia. Nous Therapy Center, Thessaloniki, Greece. Jubilee Mission Medical College & Research Institute, Thrissur, India. Pushpagiri Institute of Medical Sciences, Thiruvalla, Kerala, India. Pakistan Psychiatric Research Centre-Fountain House, Lahore, Pakistan. Faculty of Psychiatry, College of Physicians and Surgeons, Jinnah Postgraduate Medical Centre, and Jinnah Sindh Medical University in Karachi, Pakistan. Tees Esk & Wear Valleys NHS Foundation Trust, UK. Irrua Specialist Teaching Hospital, Edo State, Nigeria. University of Ottawa, The Ottawa Hospital, Ontario, Canada; Ottawa Hospital Research Institute (OHRI) Ontario, Canada. UC San Diego, California, USA. University of British Columbia, Vancouver, Canada. Alberta Health Services and the University of Calgary, Calgary, Canada. Ain Shams University, Cairo, Egypt. Ora University, Oran, Algeria. Karolinska Institutet in Stockholm, Sweden; University of Eastern Finland, Kuopio, Finland. Yonsei University College of Medicine, Seoul, Republic of Korea. Wonju College of Medicine, Wonju, Republic of Korea. University of Monastir, Monastir, Tunisia. Republican Scientific and Practical Center of Mental Health, Almaty, Kazakhstan. Gaza Community Mental Health Programme, Gaza, Palestine. Sheba Medical Center, Israel. University of Greenwich in London, United Kingdom; FHNW University of Applied Sciences and Arts Northwestern Switzerland, Switzerland; University of Texas Health Science Center, Houston, United States; Zucker Hillside Hospital, Northwell Health, and the Feinstein Institutes for Medical Research, New York. Electronic address: christoph.correll@charite.de.
Abstract summary
To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide.This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured. A χ, penalized cubic splines, linear regression, and correlation analyses were conducted.Analyzing 8,115 of 8,762 initiated surveys (representative = 75.1%), the pre-pandemic WHO-5 and P-score remained stable during the study (excluding relevant recall bias/drift), but worsened during the pandemic by 5.55 ± 17.13 (SD) and 6.74 ± 16.06 points, respectively (effect size d = 0.27 and d = 0.28). The proportion of adolescents with WHO-5 scores suggesting depression screening (<50) and major depression (<29) increased from 9% to 17% and 2% to 6%. WHO-5 worsened (descending magnitude, with cumulative effect) in adolescents with a mental or physical disorder, female gender, and with school closure. Results were similar for the P-score, with the exception of school closure (not significant) and living in a low-income country, as well as not living in a large city (significant). Changes were significantly but minimally related to COVID-19 deaths/restrictions, returning to near-pre-pandemic values after >2 years. The 3 most subjectively effective coping strategies were Internet use, exercise/walking, and social contacts.Overall, well-being/mental health worsened (small effect sizes) during the early stages of the COVID-19 pandemic, especially in vulnerable subpopulations. Identified at-risk groups, association with pandemic-related measures, and coping strategies can inform individual behaviors and global public health strategies.Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A); https://doi.org/10.1016/j.jad.2021.09.090 DIVERSITY & INCLUSION STATEMENT: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. We actively worked to promote sex and gender balance in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science.Authors & Co-authors: Solmi Marco M Thompson Trevor T Cortese Samuele S Estradé Andrés A Agorastos Agorastos A Radua Joaquim J Dragioti Elena E Vancampfort Davy D Thygesen Lau Caspar LC Aschauer Harald H Schlögelhofer Monika M Aschauer Elena E Schneeberger Andres Andres AA Huber Christian G CG Hasler Gregor G Conus Philippe P Do Cuénod Kim Q KQ von Känel Roland R Arrondo Gonzalo G Fusar-Poli Paolo P Gorwood Philip P Llorca Pierre-Michel PM Krebs Marie-Odile MO Scanferla Elisabetta E Kishimoto Taishiro T Rabbani Golam G Skonieczna-Żydecka Karolina K Brambilla Paolo P Favaro Angela A Takamiya Akihiro A Zoccante Leonardo L Colizzi Marco M Bourgin Julie J Kamiński Karol K Moghadasin Maryam M Seedat Soraya S Matthews Evan E Wells John J Vassilopoulou Emilia E Gadelha Ary A Su Kuan-Pin KP Kwon Jun Soo JS Kim Minah M Lee Tae Young TY Papsuev Oleg O Manková Denisa D Boscutti Andrea A Gerunda Cristiano C Saccon Diego D Righi Elena E Monaco Francesco F Croatto Giovanni G Cereda Guido G Demurtas Jacopo J Brondino Natascia N Veronese Nicola N Enrico Paolo P Politi Pierluigi P Ciappolino Valentina V Pfennig Andrea A Bechdolf Andreas A Meyer-Lindenberg Andreas A Kahl Kai G KG Domschke Katharina K Bauer Michael M Koutsouleris Nikolaos N Winter Sibylle S Borgwardt Stefan S Bitter Istvan I Balazs Judit J Czobor Pál P Unoka Zsolt Z Mavridis Dimitris D Tsamakis Konstantinos K Bozikas Vasilis P VP Tunvirachaisakul Chavit C Maes Michael M Rungnirundorn Teerayuth T Supasitthumrong Thitiporn T Haque Ariful A Brunoni Andre R AR Costardi Carlos Gustavo CG Schuch Felipe Barreto FB Polanczyk Guilherme G Luiz Jhoanne Merlyn JM Fonseca Lais L Aparicio Luana V LV Valvassori Samira S SS Nordentoft Merete M Vendsborg Per P Hoffmann Sofie Have SH Sehli Jihed J Sartorius Norman N Heuss Sabina S Guinart Daniel D Hamilton Jane J Kane John J Rubio Jose J Sand Michael M Koyanagi Ai A Solanes Aleix A Andreu-Bernabeu Alvaro A San José Cáceres Antonia A Arango Celso C Díaz-Caneja Covadonga M CM Hidalgo-Mazzei Diego D Vieta Eduard E Gonzalez-Peñas Javier J Fortea Lydia L Parellada Mara M Fullana Miquel A MA Verdolini Norma N Andrlíková Eva E Janků Karolina K Millan Mark J MJ Honciuc Mihaela M Moniuszko-Malinowska Anna A Łoniewski Igor I Samochowiec Jerzy J Kiszkiel Łukasz Ł Marlicz Maria M Sowa Paweł P Marlicz Wojciech W Spies Georgina G Stubbs Brendon B Firth Joseph J Sullivan Sarah S Darcin Asli Enez AE Aksu Hatice H Dilbaz Nesrin N Noyan Onur O Kitazawa Momoko M Kurokawa Shunya S Tazawa Yuki Y Anselmi Alejandro A Cracco Cecilia C Machado Ana Inés AI Estrade Natalia N De Leo Diego D Curtis Jackie J Berk Michael M Carvalho Andre F AF Ward Philip P Teasdale Scott S Rosenbaum Simon S Marx Wolfgang W Horodnic Adrian Vasile AV Oprea Liviu L Alexinschi Ovidiu O Ifteni Petru P Turliuc Serban S Ciuhodaru Tudor T Bolos Alexandra A Matei Valentin V Nieman Dorien H DH Sommer Iris I van Os Jim J van Amelsvoort Therese T Sun Ching-Fang CF Guu Ta-Wei TW Jiao Can C Zhang Jieting J Fan Jialin J Zou Liye L Yu Xin X Chi Xinli X de Timary Philippe P van Winkel Ruud R Ng Bernardo B Pena Edilberto E Arellano Ramon R Roman Raquel R Sanchez Thelma T Movina Larisa L Morgado Pedro P Brissos Sofia S Aizberg Oleg O Mosina Anna A Krinitski Damir D Mugisha James J Sadeghi-Bahmani Dena D Sheybani Farshad F Sadeghi Masoud M Hadi Samira S Brand Serge S Errazuriz Antonia A Crossley Nicolas N Ristic Dragana Ignjatovic DI López-Jaramillo Carlos C Efthymiou Dimitris D Kuttichira Praveenlal P Kallivayalil Roy Abraham RA Javed Afzal A Afridi Muhammad Iqbal MI James Bawo B Seb-Akahomen Omonefe Joy OJ Fiedorowicz Jess J Daskalakis Jeff J Yatham Lakshmi N LN Yang Lin L Okasha Tarek T Dahdouh Aïcha A Tiihonen Jari J Shin Jae Il JI Lee Jinhee J Mhalla Ahmed A Gaha Lotfi L Brahim Takoua T Altynbekov Kuanysh K Negay Nikolay N Nurmagambetova Saltanat S Jamei Yasser Abu YA Weiser Mark M Correll Christoph U CU
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