Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.
Journal: Science advances
Volume: 10
Issue: 48
Year of Publication: 2024
Affiliated Institutions:
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA , USA.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA , USA.
Division of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA , USA.
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona , Spain.
MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS BN, UK.
Glotech Inc., contractor for Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD , USA.
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome Italy.
Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE , USA.
Bradford Institute for Health Research, Bradford BD RJ, UK.
Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin , Italy.
Department of Internal Medicine, Kangwon National University, Chuncheon , Korea.
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F- Paris, France.
Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA , USA.
Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. box Skøyen, Oslo, Norway.
Interdisciplinary Program of Bioinformatics, College of Natural Sciences, Seoul National University, Seoul , Korea.
Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig , Germany.
Department of Child and Adolescent Psychiatry / Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam GD, Netherlands.
University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen RB, Netherlands.
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim , Germany.
Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France.
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO YD, UK.
College of Veterinary Medicine, Michigan State University, East Lansing, MI , USA.
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam GD, Netherlands.
Department of Mother and Child Health, Azienda USL Toscana Nord Ovest, Pisa , Italy.
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO YD, UK.
Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN , USA.
National Institute of Environmental Health Sciences, Research Triangle Park, NC , USA.
Department of Biostatistics, Epidemiology and Informatics and Department of Obstetrics and Gynecology, Perelman School of Medicine, Philadelphia, PA , USA.
South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Rondebosch , South Africa.
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim , Germany.
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA , USA.
Groningen Research Institute for Asthma and COPD, Groningen RB, Netherlands.
Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD USA.
South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, Department of Paediatrics, University of Cape Town, Rondebosch , South Africa.
Abstract summary
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, < 1.0 × 10): (cg19423175), (cg01500140), (cg13917614), (cg18247172), (cg22348356), and (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery's molecular influence on offspring health.
Authors & Co-authors:
Wang Siwen S
Casey Emma E
Sordillo Joanne J
Aguilar-Lacasaña Sofía S
Morales Berstein Fernanda F
Biedrzycki Richard J RJ
Brescianini Sonia S
Chen Su S
Hough Amy A
Isaevska Elena E
Kim Woo Jin WJ
Lecorguillé Marion M
Li Sebastian Shaobo SS
Page Christian M CM
Park Jaehyun J
Röder Stefan S
Salontaji Kristina K
Santorelli Gillian G
Sun Yidan Y
Won Sungho S
Zillich Eric E
Zillich Lea L
Annesi-Maesano Isabella I
Arshad S Hasan SH
Bustamante Mariona M
Cecil Charlotte A M CAM
Elliott Hannah R HR
Ewart Susan S
Felix Janine F JF
Gagliardi Luigi L
Håberg Siri E SE
Herberth Gunda G
Heude Barbara B
Holloway John W JW
Huels Anke A
Karmaus Wilfried W
Koppelman Gerard H GH
London Stephanie J SJ
Mumford Sunni L SL
Nisticò Lorenza L
Popovic Maja M
Rusconi Franca F
Schisterman Enrique F EF
Stein Dan J DJ
Send Tabea T
Tiemeier Henning H
Vonk Judith M JM
Vrijheid Martine M
Wiemels Joseph Leo JL
Witt Stephanie H SH
Wright John J
Yeung Edwina H EH
Zar Heather J HJ
Zenclussen Ana C AC
Zhang Hongmei H
Chavarro Jorge E JE
Hivert Marie-France MF
Study Outcome
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