A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.
Journal: NPJ Parkinson's disease
Volume: 10
Issue: 1
Year of Publication:
Affiliated Institutions:
Amsterdam UMC, Department of Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.laansma@amsterdamumc.nl.
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Amsterdam UMC, Department of Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Faculty of Health and Medicine, The University of Lancaster, Lancaster, UK.
Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Amsterdam UMC, Department Neurology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.
New Zealand Brain Research Institute, Christchurch, New Zealand.
Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.
Department of Neurology and Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Lancaster Medical School, Lancaster University, Lancaster, UK.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
GIGA-CRC in vivo imaging, University of Liège, Liège, Belgium.
Department of Neurology and Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Division of Clinical Neurology, Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, Nuffield, University of Oxford, Oxford, UK.
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.
SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Excellence Center for Advanced MR Techniques and Parkinson's Disease Center, Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Milan, Italy.
Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Neurology, Medical University of Graz, Graz, Austria.
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan.
Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Abstract summary
Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson's disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amygdala and hippocampus are not well established. We analyzed 3D T1-weighted brain MRI and clinical data from 2525 individuals with PD and 1326 controls from 22 global sources in the ENIGMA-PD consortium. We investigated disease effects using mass univariate and multivariate models on the medial thickness of 27,120 vertices of seven bilateral subcortical structures. Shape differences were observed across all Hoehn and Yahr (HY) stages, as well as correlations with motor and cognitive symptoms. Notably, we observed incrementally thinner putamen from HY1, caudate nucleus and amygdala from HY2, hippocampus, nucleus accumbens, and thalamus from HY3, and globus pallidus from HY4-5. Subregions of the thalami were thicker in HY1 and HY2. Largely congruent patterns were associated with a longer time since diagnosis and worse motor symptoms and cognitive performance. Multivariate regression revealed patterns predictive of disease stage. These cross-sectional findings provide new insights into PD subcortical degeneration by demonstrating patterns of disease stage-specific morphology, largely consistent with ongoing degeneration.
Authors & Co-authors:
Laansma Max A MA
Zhao Yuji Y
van Heese Eva M EM
Bright Joanna K JK
Owens-Walton Conor C
Al-Bachari Sarah S
Anderson Tim J TJ
Assogna Francesca F
van Balkom Tim D TD
Berendse Henk W HW
Cendes Fernando F
Dalrymple-Alford John C JC
Debove Ines I
Dirkx Michiel F MF
Druzgal Jason J
Emsley Hedley C A HCA
Fouche Jean-Paul JP
Garraux Gaëtan G
Guimarães Rachel P RP
Helmich Rick C RC
Hu Michele M
van den Heuvel Odile A OA
Isaev Dmitry D
Kim Ho-Bin HB
Klein Johannes C JC
Lochner Christine C
McMillan Corey T CT
Melzer Tracy R TR
Newman Benjamin B
Parkes Laura M LM
Pellicano Clelia C
Piras Fabrizio F
Pitcher Toni L TL
Poston Kathleen L KL
Rango Mario M
Ribeiro Leticia F LF
Rocha Cristiane S CS
Rummel Christian C
Santos Lucas S R LSR
Schmidt Reinhold R
Schwingenschuh Petra P
Squarcina Letizia L
Stein Dan J DJ
Vecchio Daniela D
Vriend Chris C
Wang Jiunjie J
Weintraub Daniel D
Wiest Roland R
Yasuda Clarissa L CL
Jahanshad Neda N
Thompson Paul M PM
van der Werf Ysbrand D YD
Gutman Boris A BA
Study Outcome
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