White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals.

Journal: Molecular psychiatry

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Affiliated Institutions:  Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany. Institute for Translational Psychiatry, University of Münster, Münster, Germany. Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milano, Italy. Institute for Mental and Physical Health and Clinical Translation School of Medicine, Deakin University, Geelong, VIC, Australia. Unit for Psychosomatics and C-L psychiatry for adults, Oslo University Hospital, Oslo, Norway. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. Centre for Neuroimaging and Cognitive Genomics, Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, University of Galway, Galway, Ireland. Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, Melbourne, VIC, Australia. Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Colombia. Department of Behavioural Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia. Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK. Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia. University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Synapsy Center, Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Univ. Grenoble Alpes, Inserm, U, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France. Mental Health Research Networking Center (CIBERSAM), ISC III, Barcelona, Spain. West Region, Institute of Mental Health, Singapore, Singapore. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. tomas.hajek@dal.ca.

Abstract summary 

Although specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD. We obtained body mass index (BMI) and diffusion tensor imaging derived fractional anisotropy (FA) from 22 white matter tracts in 899 individuals with BD, and 1287 control individuals from 20 cohorts in the ENIGMA-BD working group. In a mega-analysis, we investigated the associations between BMI, diagnosis or medication and FA. Lower FA was associated with both BD and BMI in six white matter tracts, including the corpus callosum and thalamic radiation. Higher BMI or BD were uniquely associated with lower FA in three and six white matter tracts, respectively. People not receiving lithium treatment had a greater negative association between FA and BMI than people treated with lithium in the posterior thalamic radiation and sagittal stratum. In three tracts BMI accounted for 10.5 to 17% of the negative association between the number of medication classes other than lithium and FA. Both overweight/obesity and BD demonstrated lower FA in some of the same regions. People prescribed lithium had a weaker association between BMI and FA than people not on lithium. In contrast, greater weight contributed to the negative associations between medications and FA. Obesity may add to brain alterations in BD and may play a role in effects of medications on the brain.

Authors & Co-authors:  Dietze Lorielle M F LMF McWhinney Sean R SR Favre Pauline P Abé Christoph C Alexander Nina N Barkhau Carlotta C Benedetti Francesco F Berk Michael M Bøen Erlend E Boye Birgitte B Brosch Katharina K Canales-Rodríguez Erick J EJ Cannon Dara M DM Carruthers Sean P SP Corkum Emily L V ELV Dannlowski Udo U Díaz-Zuluaga Ana M AM Dohm Katharina K Elvsåshagen Torbjørn T Flinkenflügel Kira K Fortea Lydia L Furlong Lisa S LS Goldstein Benjamin I BI Grotegerd Dominik D Gruber Marius M Haarman Bartholomeus C M BCM Howells Fleur M FM Jahanshad Neda N Jamalabadi Hamidreza H Jansen Andreas A Karantonis James A JA Kennedy Kody G KG Kircher Tilo T J TTJ Klahn Anna Luisa AL Kochunov Peter P Kraus Anna A Landén Mikael M López-Jaramillo Carlos C MacIntosh Bradley J BJ Mazza Elena E McDonald Colm C McIntosh Andrew M AM Meinert Hannah H Meinert Susanne S Melloni Elisa M T EMT Mitchell Philip B PB Nenadić Igor I Opel Nils N Phillips Mary M Piguet Camille C Polosan Mircea M Pomarol-Clotet Edith E Pouchon Arnaud A Radua Joaquim J Roberts Gloria G Ross Alex J AJ Rossell Susan L SL Salvador Raymond R Sim Kang K Soares Jair C JC Zunta-Soares Giovana B GB Stein Frederike F Straube Benjamin B Suo Chao C Teutenberg Lea L Thomas-Odenthal Florian F Thomopoulos Sophia I SI Usemann Paula P Van Rheenen Tamsyn E TE Versace Amelia A Vieta Eduard E Vilajosana Enric E Mwangi Benson B Wen Wei W Whalley Heather C HC Wu Mon-Ju MJ Andreassen Ole A OA Ching Christopher R K CRK Thompson Paul M PM Houenou Josselin J Hajek Tomas T

Study Outcome 

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Citations :  World Health Organization. Obesity and Overweight. 2021. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight .
Authors :  83
Identifiers
Doi : 10.1038/s41380-024-02784-2
SSN : 1476-5578
Study Population
Male,Female
Mesh Terms
Other Terms
Study Design
Cohort Study
Study Approach
Country of Study
Mali
Publication Country
England