Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

Journal: Nature genetics

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Affiliated Institutions:  Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA. Academic Unit Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia. Universite Lille, U-RID-AGE-LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging Diseases, Lille, France. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Departments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia. Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK. Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. Brain Center University Medical Center Utrecht, Utrecht, The Netherlands. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg University, Regensburg, Germany. Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS)-Georgia State, Georgia Tech and Emory University, Atlanta, GA, USA. Pennington Biomedical Research Center, Baton Rouge, LA, USA. Cerebral Imaging Centre, Douglas Research Centre, Montreal, Quebec, Canada. Lieber Institute for Brain Development, Baltimore, MD, USA. Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Institute of Neuroscience and Medicine (INM-), Research Center Jülich, Jülich, Germany. HU Virgen del Rocio, Instituto de Investigacion Biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, Spain. CNRS, IMN, UMR , University of Bordeaux, Bordeaux, France. Center for Multimodal Imaging and Genetics, La Jolla, CA, USA. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York City, NY, USA. School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia. INSERM U, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France. Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, USA. Department of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium. Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany. German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany. Department of Psychology, University of Oslo, Oslo, Norway. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. INSERM U, Paris Saclay University, Gif-sur-Yvette, France. Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Department of Neurology, University of California, Davis, Davis, CA, USA. Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Department of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, USA. Central Institute of Mental Health, Mannheim, Germany. Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. Icelandic Heart Association, Kopavogur, Iceland. Department of Neuromedicine and Movement, NTNU Science, Trondheim, Norway. Norwegian Centre for Mental Health Research (NORMENT), Department of Mental Health and Addiction, University of Oslo, Oslo, Norway. Product Development, Genentech, Inc., South San Francisco, CA, USA. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore City, Singapore. Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Max Planck Institute of Psychiatry, Munich, Germany. Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. German Centre for Neurodegenerative Diseases (DZNE)-Site Rostock/Greifswald, Greifswald, Germany. Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. Department of Radiology, University Clinic Greifswald, Greifswald, Germany. Departments of Epidemiology and Neurology, Erasmus MC, Rotterdam, The Netherlands. Department of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa. Department of Radiology, Mayo Clinic, Rochester, MN, USA. Altrecht Mental Health Institute, Utrecht, The Netherlands. Araya, Inc, Tokyo, Japan. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Intramural Research Program, National Institute on Aging, Baltimore, MD, USA. Division of Psychiatry, University of Edinburgh, Edinburgh, UK. Department of Clinical Science, University of Bergen, Bergen, Norway. Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA. Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR , CNRS, Université de Bordeaux, Bordeaux, France. PPLS, University of Edinburgh, Edinburgh, UK. Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Department of Neurology, University of Washington, Seattle, WA, USA. Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Department of Psychology, University of Edinburgh, Edinburgh, UK. Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U 'Trajectoires développementales Psychiatrie', Ecole Normale Supérieure Paris-Saclay, CNRS UMR , Université Paris Cité, Centre Borelli, Gif sur Yvette, France. School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia. Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany. Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. MIND Center, Jackson, MS, USA. Statistics Genetics Group, Max Planck Institute of Psychiatry, Munich, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. University Medical Center Groningen, Groningen, The Netherlands. Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Université Libre de Bruxelles, Brussels, Belgium. Departments of Psychiatry and Neuroscience, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada. Hospital for Sick Children, Toronto, Ontario, Canada. Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Translational Psychiatry, Munich, Germany. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany. Department of Psychiatry and Neuroscience, Charité-Universitätsmedizin Berlin, Berlin, Germany. Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Sevilla, Spain. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia. Institute of Molecular Biology and Biochemistry, Gottfried Schatz Center for Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria. Department of Neurology, Medical University Graz Austria, Graz, Austria. Neuroscience Research Australia, Sydney, New South Wales, Australia. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. The Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK. Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. SAMRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. Instituto de Física de Cantabria (CSIC-UC), Santander, Spain. Department of Biological Psychology and Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Department of Psychiatry, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain. Department of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. University of California, San Francisco, San Francisco, CA, USA. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden. Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA. Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA. Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.

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