Discrimination and manic symptoms in early adolescence: A prospective cohort study.

Journal: Journal of affective disorders

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Affiliated Institutions:  Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jason.nagata@ucsf.edu. Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada. Department of Management, Policy and Community Health, University of Texas Health Science Center at Houston, Houston, TX, USA. Division of Applied Psychology, School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. Military Cardiovascular Outcomes Research Program (MiCOR), Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Metis Foundation, San Antonio, TX, USA. Center for Health Sciences, SRI International, Menlo Park, CA, USA; School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.

Abstract summary 

This study aims to investigate the prospective associations between four types of perceived discrimination (country of origin, race and ethnicity, sexual orientation, and weight) and the development of manic symptoms in a diverse, nationwide sample of adolescents aged 9-14 years in the U.S.We analyzed prospective cohort data from the Adolescent Brain Cognitive Development Study (N = 7466; ages 9-14 years at Year 1 or 2 in 2017-2020; 49.1 % female; 42.1 % racial/ethnic minority). Multiple zero-inflated negative binomial analyses were conducted to examine the associations between Year 1 or 2 discrimination (by country of origin, race/ethnicity, sexual orientation, weight, sum score), and Year 3 manic symptoms (7 Up Mania scale), adjusting for covariates (age, sex, race/ethnicity, household income, parental education, sipping alcohol, puffing tobacco, anxiety symptoms, depressive symptoms, Year 1 manic symptoms, and study site).After adjusting for covariates, perceived discrimination based on country of origin (incidence rate ratio [IRR] = 1.46; 95 % confidence interval [CI] 1.15-1.86), sexual orientation (IRR = 1.36; 95 % CI 1.21-1.53), race/ethnicity (IRR = 1.28; 95 % CI 1.13-1.46), weight (IRR = 1.21 95 % CI 1.09-1.34), and sum scores (IRR = 1.18 5 % CI 1.12-1.24), were significantly associated with higher manic symptoms.Perceived discrimination based on country of origin, race/ethnicity, sexual orientation, weight, and sum scores, are prospectively associated with greater manic symptoms in adolescents. These findings underscore the need for targeted interventions to address discrimination and associated psychological impacts. Efforts to reduce discrimination and to support affected adolescents are important components of comprehensive mental health care and public health strategies.

Authors & Co-authors:  Nagata Jason M JM Wong Jennifer J Zamora Gabriel G Al-Shoaibi Abubakr A A AAA Low Patrick P Ganson Kyle T KT Testa Alexander A He Jinbo J Lavender Jason M JM Baker Fiona C FC

Study Outcome 

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Statistics
Citations : 
Authors :  10
Identifiers
Doi : S0165-0327(24)01773-7
SSN : 1573-2517
Study Population
Male,Female
Mesh Terms
Other Terms
Adolescence;Bipolar disorder;Discrimination;Mania
Study Design
Cohort Study
Study Approach
Country of Study
Publication Country
Netherlands