Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function.

Journal: bioRxiv : the preprint server for biology

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Affiliated Institutions:  National Clinical Research Center for Aging and Medicine at Huashan Hospital, MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai , China. Oxford Centre for Computational Neuroscience, Oxford, UK; Department of Computer Science, University of Warwick, Coventry, UK. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, University of Cambridge, Cambridge CB SZ, UK. Department of Psychology and Mental Health, University of Manchester, Manchester, Greater Manchester, UK. Student Affairs Department, Fudan University, Shanghai , China. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J, Mannheim, Germany. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, United Kingdom. Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J, Mannheim, Germany. NeuroSpin, CEA, Université Paris-Saclay, F- Gif-sur-Yvette, France. Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA. Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany. Institut National de la Santé et de la Recherche Médicale, INSERM U "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette, France. Institut National de la Santé et de la Recherche Médicale, INSERM U "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette; and AP-HP. Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris; France. Institut National de la Santé et de la Recherche Médicale, INSERM U "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette; and Psychiatry Department, EPS Barthélémy Durand, Etampes; France. Institut des Maladies Neurodégénératives, UMR , CNRS, CEA, Université de Bordeaux, Bordeaux, France. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. , , Göttingen, Germany. Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany. Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany. School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.

Abstract summary 

Resilience to emotional disorders is critical for adolescent mental health, especially following childhood abuse. Yet, brain signatures of resilience remain undetermined due to the differential susceptibility of the brain's emotion processing system to environmental stresses. Analyzing brain's responses to angry faces in a longitudinally large-scale adolescent cohort (IMAGEN), we identified two functional networks related to the orbitofrontal and occipital regions as candidate brain signatures of resilience. In girls, but not boys, higher activation in the orbitofrontal-related network was associated with fewer emotional symptoms following childhood abuse, but only when the polygenic burden for depression was high. This finding defined a genetic-dependent brain (GDB) signature of resilience. Notably, this GDB signature predicted subsequent emotional disorders in late adolescence, extending into early adulthood and generalizable to another independent prospective cohort (ABCD). Our findings underscore the genetic modulation of resilience-brain connections, laying the foundation for enhancing adolescent mental health through resilience promotion.

Authors & Co-authors:  Lu Han H Rolls Edmund T ET Liu Hanjia H Stein Dan J DJ Sahakian Barbara J BJ Elliott Rebecca R Jia Tianye T Xie Chao C Xiang Shitong S Wang Nan N Banaschewski Tobias T Bokde Arun L W ALW Desrivières Sylvane S Flor Herta H Grigis Antoine A Garavan Hugh H Heinz Andreas A Brühl Rüdiger R Martinot Jean-Luc JL Martinot Marie-Laure Paillère MP Artiges Eric E Nees Frauke F Orfanos Dimitri Papadopoulos DP Lemaitre Herve H Poustka Luise L Hohmann Sarah S Holz Nathalie N Fröhner Juliane H JH Smolka Michael N MN Vaidya Nilakshi N Walter Henrik H Whelan Robert R Schumann Gunter G Feng Jianfeng J Luo Qiang Q

Study Outcome 

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Citations :  Eaton S., Cornwell H., Hamilton-Giachritsis C. & Fairchild G. Resilience and young people's brain structure, function and connectivity: A systematic review. Neurosci Biobehav Rev 132, 936–956 (2022).
Authors :  36
Identifiers
Doi : 2024.09.16.612982
SSN : 2692-8205
Study Population
Male,Female
Mesh Terms
Other Terms
brain function;brain signatures of resilience;childhood abuse;emotion processing;emotional disorders;genetic-dependent
Study Design
Cohort Study
Study Approach
Country of Study
Publication Country
United States