Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis.
Journal: Neuroscience and biobehavioral reviews
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Affiliated Institutions:
Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB).
Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Department of Psychiatry, University of Nairobi, Kenya; The Science for Africa Foundation, Nairobi, Kenya.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Psychiatry, General Psychiatry Service, Treatment and Early Intervention in Psychosis Program, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Departamento de Psiquiatría, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Spain.
Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic de Barcelona, Spain.
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Deparment of Mental Health. Hospital Universitari Vall d'Hebron. Barcelona, Catalonia, Spain; Group of Psychiatry, Mental Health and Addictions, Valld'Hebron Research Institute (VHIR); Vall d'Hebron Research Institute (VHIR); Barcelona, Catalonia, Spain; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain; Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Group of Psychiatry, Mental Health and Addictions, Valld'Hebron Research Institute (VHIR); Vall d'Hebron Research Institute (VHIR); Barcelona, Catalonia, Spain. Electronic address: silvia.amoretti@vhir.org.
Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Serra-Hunter Lecturer Fellow, Department of Basic Clinal Practice, Pharmacology Unit, Universitat de Barcelona (UB), Spain. Electronic address: mezquida@recerca.clinic.cat.
Abstract summary
Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to comprehensively evaluate differences in psychopathology between individuals with and without exposure to OCs in relation to SZ and related disorders. We systematically searched PubMed, PsycINFO, and SCOPUS to identify eligible studies. A total of 4,091 records were retrieved through systematic and citation searches. 14 studies were included in the review, and 12 met the criteria for meta-analysis, involving 2,992 patients. The analysis revealed that SZ patients who had been exposed to OCs exhibited significantly higher levels of positive symptoms (SMD=0.10, 95%CI=0.01,0.20; p=0.03), general psychopathology (SMD=0.37, 95%CI=0.22,0.52; p<0.001), total clinical symptomatology (SMD=0.44, 95%CI=0.24,0.64; p<0.001) and depressive symptoms (SMD=0.47, 95%CI=0.09,0.84; p=0.01). No significant differences were found in negative symptomatology and functioning. Our results suggest that OCs are not only associated with an increased risk of developing psychosis but with more severe symptomatology.
Authors & Co-authors:
Forte Maria Florencia MF
Oliva Vincenzo V
De Prisco Michele M
Garriga Marina M
Bitanihirwe Byron B
Alameda Luis L
González-Segura Àlex À
Vieta Eduard E
Baeza Inmaculada I
Parellada Eduard E
Penadés Rafael R
Ramos-Quiroga J Antoni JA
Amoretti Silvia S
Mezquida Gisela G
Garcia-Rizo Clemente C
Study Outcome
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