Gait speed, handgrip strength, and their combination, and risk of depression in later life: Evidence from a prospective study of community-dwelling older adults.

Journal: Journal of affective disorders

Volume: 369

Issue: 

Year of Publication: 

Affiliated Institutions:  Deakin University, the Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Geelong, Victoria, Australia; College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. Electronic address: b.miteku@deakin.edu.au. Deakin University, the Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Geelong, Victoria, Australia. Deakin University, the Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Barwon Health, Geelong, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. School of Medicine, Royal Perth Hospital, University of Western Australia, Perth, Australia. Department of Family & Preventive Medicine and the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, USA. Center for Translational Geroscience, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia; Department of Clinical Neurosciences, St Vincent's Hospital, Melbourne, Victoria, Australia. Biostatistics Unit, Faculty of Health, Deakin University, Geelong, Victoria, Australia.

Abstract summary 

This study investigated the association between gait speed, handgrip strength, and their combination, and the risk for developing clinically relevant depressive symptoms in community-dwelling older adults.A secondary analysis was conducted using data from the ASPirin in Reducing Events in the Elderly study. Participants were community-dwelling older adults in Australia and the United States of America followed for a median (interquartile range) of 3.97 (2.26) years. Baseline handgrip strength and gait speed were used as exposure variables, and their combination categories were also explored. Depression was measured using the modified Center for Epidemiological Studies Depression 10-item scale (CES-D 10). Cox regression was used to estimate Adjusted Hazard Ratios (AHR) with 95 % Confidence Intervals (CI) after adjusting for a range of potential confounders.A total of 17,231 participants (55.3 % women) were included in the analysis. Slow gait and weak grip at baseline were associated with the risk of depression (AHR: 1.20; CI: 1.11-1.29 and 1.14; 1.06-1.23, respectively). The combination of the two physical performance measures was associated with a 31 % increase in the risk of depression (1.31; 1.16-1.47) and a significant dose-response association was observed for quintiles of gait and grip with depression.Although the CES-D 10 is a validated scale, it is a self-reported tool rather than a clinical diagnosis of depression.Low physical function may be a risk factor for depression in older adults. This highlights the inextricable link between the physical and mental health of older adults, which can inform potential clinical and public health prevention strategies for depression in later life.

Authors & Co-authors:  Mengist Belayneh B Lotfaliany Mojtaba M Pasco Julie A JA Agustini Bruno B Berk Michael M Williams Lana J LJ Forbes Malcolm M Woods Robyn L RL Orchard Suzanne G SG Ryan Joanne J McNeil John J JJ Owen Alice J AJ Beilin Lawrence J LJ Shah Raj C RC Espinoza Sara E SE Ganjali Shiva S Chong Trevor T-J TT Mohebbi Mohammadreza M

Study Outcome 

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Statistics
Citations : 
Authors :  18
Identifiers
Doi : 10.1016/j.jad.2024.09.155
SSN : 1573-2517
Study Population
Male,Female
Mesh Terms
Other Terms
Depression;Gait speed;Handgrip;Mental health;Mood disorders;Physical function
Study Design
Study Approach
Country of Study
Publication Country
Netherlands