Trajectory of Cognitive Decline Before and After Stroke in 14 Population Cohorts.
Journal: JAMA network open
Volume: 7
Issue: 10
Year of Publication: 2024
Affiliated Institutions:
Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Inserm U, IRD UMR, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina, Brazil.
IA&Saúde-The Artificial Intelligence and Health Research Unit, Polytechnic University of Health, CESPU, Portugal.
Department of Physical Education, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Inserm U: Neuropsychiatrie Hôpital La Colombière, BP, Montpellier, France.
Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Golgi Cenci Foundation, Abbiategrasso, Italy.
Faculty of Medicine, Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Departments of Psychiatry, Neurology, and Epidemiology, School of Medicine and School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ageing Futures Institute, University of New South Wales, Sydney, Australia.
Department of Epidemiology and Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York.
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.
Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, , Madrid, Spain.
Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.
Abstract summary
Poststroke cognitive impairment is common, but the cognitive trajectory following a first stroke, relative to prestroke cognitive function, remains unclear.To map the trajectory of cognitive function before any stroke and after stroke in global cognition and in 4 cognitive domains, as well as to compare the cognitive trajectory prestroke in stroke survivors with the trajectory of individuals without incident stroke over follow-up.The study used harmonized and pooled data from 14 population-based cohort studies included in the Cohort Studies of Memory in an International Consortium collaboration. These studies were conducted from 1993 to 2019 across 11 countries among community-dwelling older adults without a history of stroke or dementia. For this study, linear mixed-effects models were used to estimate trajectories of cognitive function poststroke relative to a stroke-free cognitive trajectory. The full model adjusted for demographic and vascular risk factors. Data were analyzed from July 2022 to March 2024.Incident stroke.The primary outcome was global cognition, defined as the standardized average of 4 cognitive domains (language, memory, processing speed, and executive function). Cognitive domain scores were formed by selecting the most commonly administered test within each domain and standardizing the scores.The study included 20 860 participants (12 261 [58.8%] female) with a mean (SD) age of 72.9 (8.0) years and follow-up of 7.51 (4.2) years. Incident stroke was associated with a substantial acute decline in global cognition (-0.25 SD; 95% CI, -0.33 to -0.17 SD), the Mini-Mental State Examination, and all cognitive domains (ranging from -0.17 SD to -0.22 SD), as well as accelerated decline in global cognition (-0.038 SD per year; 95% CI, -0.057 to -0.019 SD per year) and all domains except memory (ranging from -0.020 to -0.055 SD per year), relative to a stroke-free cognitive trajectory. There was no significant difference in prestroke slope in stroke survivors compared with the rate of decline in individuals without stroke in all cognitive measures. The mean rate of decline without a previous stroke was -0.049 SD per year (95% CI, -0.051 to -0.047 SD) in global cognition.In this cohort study using pooled data from 14 cohorts, incident stroke was associated with acute and accelerated long-term cognitive decline in older stroke survivors.
Authors & Co-authors:
Lo Jessica W JW
Crawford John D JD
Lipnicki Darren M DM
Lipton Richard B RB
Katz Mindy J MJ
Preux Pierre-Marie PM
Guerchet Maëlenn M
d'Orsi Eleonora E
Quialheiro Anna A
Rech Cassiano Ricardo CR
Ritchie Karen K
Skoog Ingmar I
Najar Jenna J
Sterner Therese Rydberg TR
Rolandi Elena E
Davin Annalisa A
Rossi Michele M
Riedel-Heller Steffi G SG
Pabst Alexander A
Röhr Susanne S
Ganguli Mary M
Jacobsen Erin E
Snitz Beth E BE
Anstey Kaarin J KJ
Aiello Allison E AE
Brodaty Henry H
Kochan Nicole A NA
Chen Yen-Ching YC
Chen Jen-Hau JH
Sanchez-Juan Pascual P
Del Ser Teodoro T
Valentí Meritxell M
Lobo Antonio A
De-la-Cámara Concepción C
Lobo Elena E
Sachdev Perminder S PS
Study Outcome
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