Abstract summary 

Despite earlier research demonstrating the immunomodulatory effects of acute and chronic exercise in many medical illnesses, there is a lack of literature evaluating the acute and chronic effects of exercise on the cytokine levels in individuals with bipolar disorder (BD) or schizophrenia (SCH). This study aims to examine the acute effects of resistance exercise on cytokines and the chronic effects of resistance exercise by 10 weeks on cytokine levels, symptoms of disease, and muscular strength in individuals with BD and SCH. The included individuals (N=10) performed a single session of band-elastic resistance exercises (six exercises, 3 sets of 12 to 15 repetitions, 60seconds of interval between sets). A sub-sample (N=6) of individuals performed a supervised band-elastic resistance exercise program (2 times a week, for 10 weeks, 6 exercises, 3 sets of 12 to 15 repetitions, 60seconds of interval). We verified for acute effects: IL-2 (P=0.0085) and IL-4 (P=0.0253) levels increased, while IL-6 decreased (P=0.0435), and for chronic effects: increased IL-2 and IL-4 levels (significant effect size - Pre vs Post), a decrease in disease symptoms, and an increase in muscular strength. This study adds to what is already known about how resistance exercises affect people with BD and SCH in both short-term (systemic cytokines levels) and long-term (symptoms of disease, muscular strength, and systemic cytokines levels).

Authors & Co-authors:  Dos Santos Gustavo Gusmão GG Bachi André Luis Lacerda ALL Rangel Sara Coelho SC Silva Nali Luiz Henrique da LHD Daca Timóteo T do Amaral Jonatas Bussador JB Juliano Yara Y Natrielli-Filho Decio Gilberto DG Rossi Fabricio Eduardo FE Gil Saulo S Lafer Beny B Neves Lucas Melo LM

Study Outcome 

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