Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.
Journal: Human brain mapping
Volume: 45
Issue: 11
Year of Publication: 2024
Affiliated Institutions:
School of Psychology, University of Auckland, Auckland, New Zealand.
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Institut de neurosciences de la Timone UMR , Aix-Marseille Université & CNRS, Marseille, France.
Holland Bloorview Kids Rehabilitation Hospital, Institute for Biomedical Engineering, University of Toronto, Toronto, Canada.
National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.
BC Children's Research Institute and the University of British Columbia, Vancouver, Canada.
Department of Psychiatry, Columbia University Irving Medical Center and the New York State Psychiatric Institute, New York, New York, USA.
Department & Institute of Psychiatry, University of Sao Paulo, Medical School, Sao Paulo, Brazil.
The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Federal University of São Paulo, São Paulo, Brazil.
British Columbia Children's Hospital, British Columbia Mental Health and Substance Use Services, University of British Columbia, Vancouver, Canada.
Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Laboratório de Neurociências Integrativas (LINC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Centre for Social and Early Emotional Development and School of Psychology, Deakin University, Geelong, Australia.
Department of Psychiatry, Section on Neurodevelopment and Psychosis and the Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Biomedicine, University of Bergen, Bergen, Norway.
Center for MR Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Interdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
IRCCS Stella Maris Foundation, Pisa, Italy.
Department of Psychiatry, UNIFESP, São Paulo, Brazil.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Department of Psychiatry and Center for ADHD Research, Oregon Health & Science University, Portland, Oregon, USA.
Department of Psychiatry, The Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pisa Division, National Institute for Nuclear Physics (INFN), Pisa, Italy.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Child and Adolescent Psychiatry & Accare Child Study Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Holland Bloorview Kids Rehabilitation Hospital, Department of Pediatrics, Temetry School of Medicine, University of Toronto, Toronto, Canada.
Karakter University Center for Child and Adolescent Psychiatry, Nijmegen, The Netherlands.
New York State Psychiatric Institute/CUIMC, New York, New York, USA.
Division of Child and Adolescent Psychiatry, Department of Psychiatry, University Hospital Lausanne, Lausanne, Switzerland.
Pediatric OCD Consultation Clinic, SJH, Hamilton, Canada.
Department of Psychiatry, University of Oxford, Oxford, UK.
Trinity College Dublin, Dublin, Ireland.
School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.
Graduate Program of Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.
Academic Center Child and Youth Psychiatry, Levvel, Amsterdam, The Netherlands.
Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
Laboratory of Psychiatric Neuroimaging (LIM-), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Division of Psychological and Social Medicine and Developmental Neurosciences & Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.
Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
National Institutes of Health/National Institute of Mental Health, Bethesda, Maryland, USA.
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Madrid, Spain.
Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
QIMR Berghofer Medical Research Institute, Herston, Australia.
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Abstract summary
Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.
Authors & Co-authors:
Kurth F F
Schijven D D
van den Heuvel O A OA
Hoogman M M
van Rooij D D
Stein D J DJ
Buitelaar J K JK
Bölte S S
Auzias G G
Kushki A A
Venkatasubramanian G G
Rubia K K
Bollmann S S
Isaksson J J
Jaspers-Fayer F F
Marsh R R
Batistuzzo M C MC
Arnold P D PD
Bressan R A RA
Stewart S E SE
Gruner P P
Sorensen L L
Pan P M PM
Silk T J TJ
Gur R C RC
Cubillo A I AI
Haavik J J
O'Gorman Tuura R L RL
Hartman C A CA
Calvo R R
McGrath J J
Calderoni S S
Jackowski A A
Chantiluke K C KC
Satterthwaite T D TD
Busatto G F GF
Nigg J T JT
Gur R E RE
Retico A A
Tosetti M M
Gallagher L L
Szeszko P R PR
Neufeld J J
Ortiz A E AE
Ghisleni C C
Lazaro L L
Hoekstra P J PJ
Anagnostou E E
Hoekstra L L
Simpson B B
Plessen J K JK
Deruelle C C
Soreni N N
James A A
Narayanaswamy J J
Reddy J Y JY
Fitzgerald J J
Bellgrove M A MA
Salum G A GA
Janssen J J
Muratori F F
Vila M M
Giral M Garcia MG
Ameis S H SH
Bosco P P
Remnélius K Lundin KL
Huyser C C
Pariente J C JC
Jalbrzikowski M M
Rosa P G PG
O'Hearn K M KM
Ehrlich S S
Mollon J J
Zugman A A
Christakou A A
Arango C C
Fisher S E SE
Kong X X
Franke B B
Medland S E SE
Thomopoulos S I SI
Jahanshad N N
Glahn D C DC
Thompson P M PM
Francks C C
Luders E E
Study Outcome
Source Link: Visit source