Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

Journal: medRxiv : the preprint server for health sciences

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Affiliated Institutions:  Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Psychiatry and Behavioral Sciences, Texas A&M University, College Station, Texas, USA. Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA. PROMENTA Centre, Department of Psychology, University of Oslo, Oslo, Norway. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Institute for Genomics in Health, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA. Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Bristol Medical School, Population Health Sciences, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. Division of Medicine, Human Genetics, Vanderbilt University, Nashville, Tennessee, USA. Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. Center for Human Genetics, University of Marburg, Marburg, Germany. Dept. of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany. Helsinki Institute of Life Science, Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland. Faculty of Medicine, Department of Psychology and Logopedics, SleepWell Research Program, University of Helsinki, Helsinki, Finland. School of Medicine, Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. College of Medicine and Veterinary Medicine, Institute of Genetics and Cancer; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway. Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway. Division of Clinical Neuroscience, Department of Research and Innovation; Musculoskeletal Health, Oslo University Hospital, Oslo, Norway. Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA. Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway. Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA. Department of Genes and Environment, Max-Planck Institute of Psychiatry, Munich, Germany. Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany. Psychiatry, Center for Precision Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly, Switzerland. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. Department of Statistics, Miami University, Oxford, Ohio, USA. Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Faculty of Nursing and Health Science, Nord University, Levanger, Norway. Department of Psychiatry, Hospital Namsos, Nord-Trøndelag Health Trustt, Namsos, Norway. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Tanenbaum Centre for Pharmacogenetics, Molecular Brain Sciences Department, Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. Psychological Medicine, University of Otago, Christchurch, New Zealand. Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia. National Institute of Mental Health, Human Genetics Branch, National Institutes of Health, Bethesda, Maryland, USA. National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, Maryland, USA. Department of Psychology, Zentrum für Psychotherapie, Humboldt-Universität zu Berlin, Berlin, Germany. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Social and Behavioral Science, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia. andMe, Sunnyvale, CA, USA. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. UCL Division of Psychiatry, University College London, London, UK. Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK. Brain and Mind Centre, University of Sydney, Sydney, Australia. Department of Neuroscience, Laboratory of Neural Plasticity, University of Copenhagen, Copenhagen, Denmark. Faculty of Medicine, Department of Psychology and Logopedics and SleepWell Research Program, University of Helsinki, Helsinki, Finland. UVM Medical Center, Department of Psychiatry, University of Vermont, Burlington, Vermont, USA. NORMENT Centre, University of Oslo, Oslo, Norway. Department of Psychiatry, Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark. Department of Biomedicine, Aarhus University, Aarhus, Denmark. The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark. Faculty of Medicine, School of Public Health, University of Queensland, Herston, Queensland, Australia. Psychiatry, University of California San Diego, La Jolla, CA, USA. Amsterdam Neuroscience; Amsterdam Public Health, Amsterdam University Medical Center, Amsterdam, Netherlands. Twin Register and Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Psychiatry, University of Tartu, Tartu, Estonia. Department of Psychiatry, University of Marburg, Marburg, Germany. Psychology, Clinical Psychology, Experimental Psychopathology and Psychotherapy, University of Marburg, Marburg, Germany. School of Social Sciences, Department of Psychology, University of Mannheim, Mannheim, Germany. Department of Mental Health, Institute for Translational Psychiatry, University of Muenster, Muenster, Germany. Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt, Germany. Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. School of Medicine, Psychiatry, University of Utah, Salt Lake City, Utah, USA. Department of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany. Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, Würzburg, Germany. Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, Texas, USA.

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