Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments.

Journal: JAACAP open

Volume: 2

Issue: 2

Year of Publication: 

Affiliated Institutions:  Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Universidade Federal de Pelotas (UFPEL), Pelotas, Brazil. King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom. Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom, Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom and with Eberhard Karls University of Tübingen, Tübingen, Germany. Human and Social Development, Human Sciences Research Council, Pietermaritzburg, South Africa and Medical Research Council/Wits Developmental Pathways for Health Research Unit, University of the Witwatersrand, Johannesburg, South Africa. The George Washington University, Washington, DC, United States. University of California, Davis, Davis, CA, United States.

Abstract summary 

To present the protocol and methods for the prospective longitudinal assessments-including clinical and digital phenotyping approaches-of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo) study, which comprises Brazilian adolescents stratified at baseline by risk of developing depression or presence of depression.Of 7,720 screened adolescents aged 14 to 16 years, we recruited 150 participants (75 boys, 75 girls) based on a composite risk score: 50 with low risk for developing depression (LR), 50 with high risk for developing depression (HR), and 50 with an active untreated major depressive episode (MDD). Three annual follow-up assessments were conducted, involving clinical measures (parent- and adolescent-reported questionnaires and psychiatrist assessments), active and passive data sensing via smartphones, and neurobiological measures (neuroimaging and biological material samples). Retention rates were 96% (Wave 1), 94% (Wave 2), and 88% (Wave 3), with no significant differences by sex or group ( > .05). Participants highlighted their familiarity with the research team and assessment process as a motivator for sustained engagement.This protocol relied on novel aspects, such as the use of a WhatsApp bot, which is particularly pertinent for low- to-middle-income countries, and the collection of information from diverse sources in a longitudinal design, encompassing clinical data, self-reports, parental reports, Global Positioning System (GPS) data, and ecological momentary assessments. The study engaged adolescents over an extensive period and demonstrated the feasibility of conducting a prospective follow-up study with a risk-enriched cohort of adolescents in a middle-income country, integrating mobile technology with traditional methodologies to enhance longitudinal data collection.

Authors & Co-authors:  Piccin Jader J Viduani Anna A Buchweitz Claudia C Pereira Rivka B RB Zimerman Aline A Amando Guilherme R GR Cosenza Victor V Ferreira Leonardo Z LZ McMahon Natália A G NAG Melo Ramásio F RF Richter Danyella D Reckziegel Frederico D S FDS Rohrsetzer Fernanda F Souza Laila L Tonon André C AC Costa-Valle Marina Tuerlinckx MT Zajkowska Zuzanna Z Araújo Ricardo Matsumura RM Hauser Tobias U TU van Heerden Alastair A Hidalgo Maria Paz MP Kohrt Brandon A BA Mondelli Valeria V Swartz Johnna R JR Fisher Helen L HL Kieling Christian C

Study Outcome 

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Statistics
Citations :  GBD 2019 Mental Disorders Collaborators Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022;9(2):137–150. doi: 10.1016/S2215-0366(21)00395-3.
Authors :  26
Identifiers
Doi : 10.1016/j.jaacop.2023.11.002
SSN : 2949-7329
Study Population
Male,Female
Mesh Terms
Other Terms
adolescence;cohort;depression;digital phenotyping;risk score
Study Design
Cohort Study,Longitudinal Study
Study Approach
Country of Study
Publication Country
United States