Associations between fruit and vegetable intakes and incident depression in middle-aged and older adults from 10 diverse international longitudinal cohorts.
Journal: Journal of affective disorders
Volume: 359
Issue:
Year of Publication: 2024
Affiliated Institutions:
Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia. Electronic address: a.matison@unsw.edu.au.
The University of Sydney, Faculty of Medicine and Health, New South Wales, Australia; University Centre for Rural Health, Northern Rivers, Lismore, University of Sydney, New South Wales, Australia.
School of Psychology and Public Health, La Trobe University, Victoria, Australia.
Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia.
Department of Biomedical & Nutritional Sciences, Center for Population Health, University of Massachusetts Lowell, Lowell, USA.
Inserm U, IRD UMR, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina, Brazil.
Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina, Brazil; IA&Saúde - The Artificial Intelligence and Health Research Unit, Instituto Politécnico de Saúde do Norte, CESPU, Vila Nova de Famalicão, Portugal.
Federal University of Santa Catarina, Program in Postgraduate Physical Education, Santa Catarina, Brazil.
Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging at the Amsterdam University Medical Center, Amsterdam, Netherlands.
Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Department of Neurology, Columbia University, New York, NY, USA.
Lab of Neuropsychology & Behavioral Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece.
University of Ibadan, World Health Organization Collaborating Centre for Research and Training in Mental Health, Neurosciences and Substance Abuse, Department of Psychiatry, Ibadan, Nigeria.
Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
Jeffrey Cheah School of Medicine & Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia.
UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia; Neuroscience Research Australia, Sydney, Australia.
National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
Department of Psychological Medicine, National University of Singapore, Singapore.
Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, New South Wales, Australia.
Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia; Department of Developmental Disability Neuropsychiatry (DN), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia.
Abstract summary
Emerging observational evidence supports a role for higher fruit and vegetable intake in protecting against the development of depression. However, there is a scarcity of research in older adults or in low- to middle-income countries (LMICs).Participants were 7801 community-based adults (mean age 68.6 ± 8.0 years, 55.8 % female) without depression, from 10 diverse cohorts, including four cohorts from LMICs. Fruit and vegetable intake was self-reported via comprehensive food frequency questionnaire, short food questionnaire or diet history. Depressive symptoms were assessed using validated measures, and depression defined applying validated cut-offs. The associations between baseline fruit and vegetable intakes and incident depression over a follow-up period of three to nine years were examined using Cox regression. Analyses were performed by cohort with results meta-analysed.There were 1630 cases of incident depression (21 % of participants) over 40,258 person-years of follow-up. Higher intake of fruit was associated with a lower risk of incident depression (HR 0.87, 95%CI [0.77, 0.99], I = 4 %). No association was found between vegetable intake and incident depression (HR 0.93, 95%CI [0.84, 1.04], I = 0 %).Diverse measures used across the different cohorts and the modest sample size of our study compared with prior studies may have prevented an association being detected for vegetable intake.Our study supports a role for fruit, but not vegetable intake in protecting against depression. Research investigating different types of fruits and vegetables using standardised measures in larger cohorts of older adults from low- and middle-income countries is warranted.
Authors & Co-authors:
Matison Annabel P AP
Flood Victoria M VM
Lam Ben C P BCP
Lipnicki Darren M DM
Tucker Katherine L KL
Preux Pierre-Marie PM
Guerchet Maëlenn M
d'Orsi Eleonora E
Quialheiro Anna A
Rech Cassiano R CR
Skoog Ingmar I
Najar Jenna J
Rydberg Sterner Therese T
Scarmeas Nikolaos N
Kosmidis Mary H MH
Yannakoulia Mary M
Gureje Oye O
Ojagbemi Akin A
Bello Toyin T
Shahar Suzana S
Fakhruddin Nik N I N M NNINM
Rivan Nurul F M NFM
Anstey Kaarin J KJ
Cherbuin Nicolas N
Mortby Moyra E ME
Ho Roger R
Brodaty Henry H
Sachdev Perminder S PS
Reppermund Simone S
Mather Karen A KA
Study Outcome
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