Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia.

Journal: BMC psychiatry

Volume: 15

Issue: 

Year of Publication: 2016

Affiliated Institutions:  Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, , People's Republic of China. @.com. Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China. liangsx@ihep.ac.cn. Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. pulv@.com. Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China. songyn@ihep.ac.cn. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, , People's Republic of China. mwansisya@yahoo.co.uk. Department of Medicine, Yale-New Haven Hospital, Yale School of Medicine, New Haven, CT, USA. qing.yang@yale.edu. Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. liufish@.com. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, , People's Republic of China. zningl@.com. Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China. shanbc@ihep.ac.cn. Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, , People's Republic of China. x.zhimin@.com.

Abstract summary 

Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs ("auditory hallucination" AH group), and 31 never experienced AVHs ("no hallucination" NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl's gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.Abnormalities of cortical thickness in the Heschl's gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.

Authors & Co-authors:  Chen Xudong X Liang Shengxiang S Pu Weidan W Song Yinnan Y Mwansisya Tumbwene E TE Yang Qing Q Liu Haihong H Liu Zhening Z Shan Baoci B Xue Zhimin Z

Study Outcome 

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Citations :  Insel TR. Rethinking schizophrenia. Nature. 2010;468(7321):187–193. doi: 10.1038/nature09552.
Authors :  10
Identifiers
Doi : 152
SSN : 1471-244X
Study Population
Male,Female
Mesh Terms
Adolescent
Other Terms
Study Design
Study Approach
Country of Study
Mali
Publication Country
England