Physical multimorbidity predicts the onset and persistence of anxiety: A prospective analysis of the Irish Longitudinal Study on Ageing.

Journal: Journal of affective disorders

Volume: 309

Issue: 

Year of Publication: 2022

Affiliated Institutions:  Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, CB PT, UK. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: shinji@yuhs.ac. Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain; Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France. Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. Italian Agency for Development Cooperation, Street, Amarat, Khartoum, Sudan. Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain. Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı (Vatan Street), Fatih, İstanbul, Turkey. School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey BT ED, Northern Ireland, UK. Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy. Yonsei University College of Medicine, Seoul, Republic of Korea. Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain; ICREA, Pg. Lluis Companys , Barcelona, Spain.

Abstract summary 

The aims of the present study were to examine prospective associations of multimorbidity (i.e., ≥2 chronic conditions) at baseline with incident and persistent anxiety over a two-year follow-up period among Irish older adults, and to quantify the extent to which sleep, pain, and disability mediate the multimorbidity-anxiety relationship.Data from The Irish Longitudinal Study on Aging (TILDA) conducted between 2009 and 2011 with a follow-up after two years were analyzed. Anxiety referred to score ≥ 8 on the anxiety section of the Hospital Anxiety and Depression Scale. Lifetime diagnosis of 14 chronic conditions was obtained. Outcomes were incident and persistent anxiety at two-year follow-up.Data on 5871 adults aged ≥50 years at baseline were analyzed [Mean (SD) age 63.3 (9.0) years; 51.2% women]. After adjustment for potential confounders, compared to no chronic physical conditions at baseline, ≥3 chronic conditions were associated with a significant 1.89 (95% CI = 1.16-3.08) times higher risk for new onset anxiety at follow-up. Furthermore, having 1, 2, and ≥3 conditions at baseline were associated with significant 1.48 (95% CI 1.02, 2.14), 1.74 (95% CI 1.19, 2.53), and 1.84 (95% CI 1.27, 2.68) times higher risk for persistent anxiety at follow-up. Sleep problems, pain, and disability were identified as significant mediators, explaining 22.9%-37.8% of the associations.Multimorbidity was associated with both new onset and persistent anxiety among Irish older adults. Future interventional studies should examine whether addressing the identified mediators may lead to lower risk for incident or persistent anxiety among those with physical multimorbidity.

Authors & Co-authors:  Smith Lee L Shin Jae Il JI Jacob Louis L Schuch Felipe F Pizzol Damiano D López Sánchez Guillermo F GF Soysal Pinar P Tully Mark A MA Butler Laurie T LT Barnett Yvonne Y Veronese Nicola N Park Seoyeon S Koyanagi Ai A

Study Outcome 

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Statistics
Citations : 
Authors :  13
Identifiers
Doi : 10.1016/j.jad.2022.04.022
SSN : 1573-2517
Study Population
Male,Female
Mesh Terms
Aged
Other Terms
Anxiety;Cohort;Epidemiology;Multimorbidity;Older adults
Study Design
Longitudinal Study
Study Approach
Country of Study
Publication Country
Netherlands