Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study.

Journal: Environment international

Volume: 94

Issue: 

Year of Publication: 2018

Affiliated Institutions:  Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Institute of Environmental Medicine (IMM), C, Metals and Health, Box , Stockholm, Sweden. University of Rochester Medical Center, School of Medicine and Dentistry, Elmwood Ave, Box , Rochester, NY , USA. The Northern Ireland Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Coleraine Campus, Cromore Road, Coleraine, Co. Londonderry BT SA, Northern Ireland, United Kingdom. Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden. Institute of Environmental Medicine (IMM), C, Metals and Health, Box , Stockholm, Sweden. The Child Development Centre, Ministry of Health, Mahé, Seychelles. Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Institute of Environmental Medicine (IMM), C, Metals and Health, Box , Stockholm, Sweden. Electronic address: karin.broberg@ki.se.

Abstract summary 

ATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.To evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Nutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008-2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers.Seven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p<0.001 to 0.013). One SNP (ABCC1 rs11075290) was also significantly associated with neurodevelopment; children born to mothers with rs11075290 CC genotype (mean hair Hg 3.6ppm) scored on average 2 points lower on the Mental Development Index (MDI) and 3 points lower on the Psychomotor Development Index (PDI) than children born to mothers with TT genotype (mean hair Hg 4.7ppm) while children with the CT genotype (mean hair Hg 4.0ppm) had intermediate BSID scores.Genetic variation in ABC transporter genes was associated with maternal hair Hg concentrations. The implications for MeHg dose in the developing child and neurodevelopmental outcomes need to be further investigated.

Authors & Co-authors:  Engström Karin K Love Tanzy M TM Watson Gene E GE Zareba Grazyna G Yeates Alison A Wahlberg Karin K Alhamdow Ayman A Thurston Sally W SW Mulhern Maria M McSorley Emeir M EM Strain J J JJ Davidson Philip W PW Shamlaye Conrad F CF Myers G J GJ Rand Matthew D MD van Wijngaarden Edwin E Broberg Karin K

Study Outcome 

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Statistics
Citations :  Aye IL, Paxton JW, Evseenko DA, Keelan JA. Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes. Placenta. 2007;28:868–877.
Authors :  17
Identifiers
Doi : 10.1016/j.envint.2016.05.027
SSN : 1873-6750
Study Population
Female,Mothers
Mesh Terms
ATP-Binding Cassette Transporters
Other Terms
ABC transporter;MDR1;MRP1;MRP2;Neurodevelopment;p-Glycoprotein
Study Design
Cohort Study
Study Approach
Country of Study
Seychelles
Publication Country
Netherlands