Case Report: Nakalanga Syndrome Revisited: Long-Term Follow-Up of a Patient Living in Western Uganda, 1994-2018.

Journal: The American journal of tropical medicine and hygiene

Volume: 104

Issue: 3

Year of Publication: 2022

Affiliated Institutions:  Practice for Child and Adolescent Health, Baden-Baden, Germany. Kabarole District Health Services, Fort Portal, Uganda. Kagando School of Nursing and Midwifery, Kasese, Uganda. Kabale University, School of Medicine, Kabale, Uganda. Global Health Institute, University of Antwerp, Antwerp, Belgium. Vector Control Unit, Ministry of Health, Fort Portal, Uganda. University of Alberta, Edmonton, Canada. Department of Pediatrics, Regional Referral Hospital, Fort Portal, Uganda.

Abstract summary 

Nakalanga syndrome is a childhood developmental disorder that has been reported from various parts of sub-Saharan Africa with the major sign of retarded growth, regularly combined with physical deformities, impaired mental and pubertal development, and epilepsy. We present a follow-up over a 24-year period of a patient living in the Itwara onchocerciasis focus of western Uganda. We demonstrate the strong similarity of Nakalanga syndrome to the more recently described Nodding syndrome, and we discuss the possible causation of both disorders by onchocerciasis. We suggest that the growing knowledge about the tight interconnections between Nakalanga and nodding syndrome, other forms of epilepsy, and onchocerciasis should be taken into consideration in a revised classification system.

Authors & Co-authors:  Kaiser Christoph C Mugisa Christine C Kisembo Donozio D Gumisiriza Nolbert N Colebunders Robert R Tukesiga Ephraim E Kipp Walter W Asaba George G

Study Outcome 

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Statistics
Citations :  Raper AB, Ladkin RG, 1950. Endemic dwarfism in Uganda. East Afr Med J 27: 339–359.
Authors :  8
Identifiers
Doi : 10.4269/ajtmh.20-0979
SSN : 1476-1645
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Study Design
Case Study,Cross Sectional Study
Study Approach
Country of Study
Uganda
Publication Country
United States