Abstract summary 

To examine the preliminary impact of group cognitive behavioral therapy and multiple family group-based family strengthening to address HIV stigma and improve the mental health functioning of adolescents living with HIV in Uganda.We analyzed data from the Suubi4Stigma study, a 2-year pilot randomized clinical trial that recruited adolescents living with HIV (10-14 years) and their caregivers (n = 89 dyads), from 9 health clinics. We fitted separate three-level mixed-effects linear regression models to test the effect of the interventions on adolescent outcomes at 3 and 6 months post intervention initiation.The average age was 12.2 years and 56% of participants were females. Participants in the multiple family group-based family strengthening intervention reported lower levels of internalized stigma (mean difference = -0.008, 95% CI = -0.015, -0.001, P = .025) and depressive symptoms at 3 months (mean difference = -0.34, 95% CI = -0.53, -0.14, P < .001), compared with usual care. On the other hand, participants in the group cognitive behavioral therapy intervention reported lower levels of anticipated stigma at 3 months (mean difference = -0.039, 95% CI = -0.072, -0.006), P = .013) and improved self-concept at 6 months follow-up (mean difference = 0.04, 95% CI = 0.01, 0.01, P = .025).Outcome trends from this pilot study provide compelling evidence to support testing the efficacy of these group-based interventions on a larger scale.The study is registered in the Clinical trials.gov database (Identifier #: NCT04528732).

Authors & Co-authors:  Nabunya Proscovia P Ssewamala Fred M FM Kizito Samuel S Mugisha James J Brathwaite Rachel R Neilands Torsten B TB Migadde Herbert H Namuwonge Flavia F Ssentumbwe Vicent V Najjuuko Claire C Sensoy Bahar Ozge O Mwebembezi Abel A McKay Mary M MM

Study Outcome 

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