Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis.

Journal: Brain sciences

Volume: 10

Issue: 10

Year of Publication: 

Affiliated Institutions:  Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju , Korea. Yonsei University College of Medicine, Seoul , Korea. Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO , USA. College of Medicine, Gyeongsang National University, Jinju , Korea. Department of Pediatrics, Yonsei University College of Medicine, Seoul , Korea. Severance Hospital, Yonsei University College of Medicine, Seoul , Korea. Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do , Korea. Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju , Korea. Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE AB, UK. Department of Pediatrics, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LUODZ, UK. CESP, Inserm UMR, Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, Le Kremlin Bicêtre, France. Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, CIBERSAM, Barcelona, Spain. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London SE AZ, UK. Department of Psychiatry, University of Toledo Medical Center, Toledo, OH , USA. Department of Internal Medicine IV, Medical University Innsbruck, Anichstraße , Innsbruck, Austria. Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, SE- Linköping, Sweden. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of the Parnaiba Delta, Parnaiba -, Brazil. Department of Basic Sciences, Medicine Faculty of Tunis, Tunis El Manar University, Rue Djebel Lakdar, Tunis , Tunisia. University Hospital, University of São Paulo, São Paulo CEP -, Brazil. Centre for Addiction & Mental Health, Toronto, ON MJ H, Canada. Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Novara, Italy. The Stockholm Center for Health and Social Change (SCOHOST), Södertörn University, Huddinge, Sweden. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB PT, UK. Department of Psychology, University of Greenwich, London SE LS, UK.

Abstract summary 

This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.

Authors & Co-authors:  Lee Jinhee J Son Min Ji MJ Son Chei Yun CY Jeong Gwang Hun GH Lee Keum Hwa KH Lee Kwang Seob KS Ko Younhee Y Kim Jong Yeob JY Lee Jun Young JY Radua Joaquim J Eisenhut Michael M Gressier Florence F Koyanagi Ai A Stubbs Brendon B Solmi Marco M Rais Theodor B TB Kronbichler Andreas A Dragioti Elena E Vasconcelos Daniel Fernando Pereira DFP Silva Felipe Rodolfo Pereira da FRPD Tizaoui Kalthoum K Brunoni André Russowsky AR Carvalho Andre F AF Cargnin Sarah S Terrazzino Salvatore S Stickley Andrew A Smith Lee L Thompson Trevor T Shin Jae Il JI Fusar-Poli Paolo P

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Lyall K., Croen L., Daniels J., Fallin M.D., Ladd-Acosta C., Lee B.K., Park B.Y., Snyder N.W., Schendel D., Volk H., et al. The changing epidemiology of autism spectrum disorders. Annu. Rev. Public Health. 2017;38:81–102. doi: 10.1146/annurev-publhealth-031816-044318.
Authors :  30
Identifiers
Doi : 692
SSN : 2076-3425
Study Population
Male,Female
Mesh Terms
Other Terms
Bayesian false-discovery probability (BFDP);Genome-Wide Association Studies (GWAS);autism spectrum disorder;false positive report probability (FPRP);meta-analysis
Study Design
Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
Switzerland