Influence of light exposure during early life on the age of onset of bipolar disorder.

Journal: Journal of psychiatric research

Volume: 64

Issue: 

Year of Publication: 2016

Affiliated Institutions:  Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany. Electronic address: michael.bauer@uniklinikum-dresden.de. ChronoRecord Association, Fullerton, CA, USA. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, Oslo, Norway. Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece. Unit of Clinical Pharmacology, University-Hospital of Cagliari, Italy. Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany. Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany. Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA , Australia. Psychiatrie, GH Saint-Louis - Lariboisière - F. Widal, AP-HP, INSERM UMR-S, Faculté de Médecine, Université D. Diderot, Paris, France; Fondation FondaMental, Créteil, France. Department of Psychiatry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva Mental Health Center, Beer Sheva, Israel. IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria , Australia; Department of Psychiatry, ORYGEN Youth Health Research Centre, Centre for Youth Mental Health and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria , Australia. Department of Molecular Medicine and Department of Mental Health (DAI), University of Siena and University of Siena Medical Center (AOUS), Siena, Italy. Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong. Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Sardinia, Italy. IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria , Australia; Department of Psychiatry, University of Melbourne, Parkville, Victoria , Australia. AP-HP, Hôpitaux Universitaires Henri-Mondor, INSERM U (IMRB), Université Paris Est, Créteil, France; Fondation FondaMental, Créteil, France. Department of Psychiatry & Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, USA. rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Palo Alto, CA, USA. Department of Psychiatry, University Hospital of Alava, University of the Basque Country, CIBERSAM, Vitoria, Spain. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan. Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, AB, Canada. Department of Psychiatry, Institute of Clinical Medicine, University of Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland. Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. BIPOLAR Zentrum Wiener Neustadt, Wiener Neustadt, Austria. Department of Affective Disorders, Q, Mood Disorders Research Unit, Aarhus University Hospital, Denmark. Bipolar Disorder Research Program, Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. Mood Disorders Program, Fundacion San Vicente de Paul, Department of Psychiatry, Universidad de Antioquia, Medellín, Colombia. Department of Psychiatry, University of Massachusetts, Worcester, MA, USA. Michigan State University College of Human Medicine, Traverse City Campus, Traverse City, MI, USA. Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Research and Development, Psychiatry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Department of Psychiatry, University of California San Diego, San Diego, CA, USA. Deparment of Psychiatry, Diego Portales University, Santiago, Chile. UCT/MRC Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe-University Frankfurt am Main, Germany. Department of Psychiatry, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA. Department of Neuroscience and Mental Health, Federal University of Bahia, Salvador, Brazil. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. Bipolar Disorder Program, Neuroscience Institute, Favaloro University, Buenos Aires, Argentina. Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. City of Helsinki, Department of Social Services and Health Care, Psychiatry, Helsinki, Finland. Schizophrenia & Affective Disorders Research Project, Tokyo Metropolitan Institute of Medical Science, Seatagaya, Tokyo, Japan. Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Department of Psychiatry, NIMHANS, Bangalore , India. Department of Psychology, Chapman University, Orange, CA, USA. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior University of California Los Angeles (UCLA), Los Angeles, CA, USA.

Abstract summary 

Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association.Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 41.3 S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation.More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model.Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

Authors & Co-authors:  Bauer Michael M Glenn Tasha T Alda Martin M Andreassen Ole A OA Angelopoulos Elias E Ardau Raffaella R Baethge Christopher C Bauer Rita R Baune Bernhard T BT Bellivier Frank F Belmaker Robert H RH Berk Michael M Bjella Thomas D TD Bossini Letizia L Bersudsky Yuly Y Wo Cheung Eric Yat EY Conell Jörn J Del Zompo Maria M Dodd Seetal S Etain Bruno B Fagiolini Andrea A Frye Mark A MA Fountoulakis Kostas N KN Garneau-Fournier Jade J Gonzalez-Pinto Ana A Gottlieb John F JF Harima Hirohiko H Hassel Stefanie S Henry Chantal C Iacovides Apostolos A Isometsä Erkki T ET Kapczinski Flávio F Kliwicki Sebastian S König Barbara B Krogh Rikke R Kunz Mauricio M Lafer Beny B Larsen Erik R ER Lewitzka Ute U Lopez-Jaramillo Carlos C MacQueen Glenda G Manchia Mirko M Marsh Wendy W Martinez-Cengotitabengoa Mónica M Melle Ingrid I Monteith Scott S Morken Gunnar G Munoz Rodrigo R Nery Fabiano G FG O'Donovan Claire C Osher Yamima Y Pfennig Andrea A Quiroz Danilo D Ramesar Raj R Rasgon Natalie N Reif Andreas A Ritter Philipp P Rybakowski Janusz K JK Sagduyu Kemal K Miranda-Scippa Ângela  Severus Emanuel E Simhandl Christian C Stein Dan J DJ Strejilevich Sergio S Sulaiman Ahmad Hatim AH Suominen Kirsi K Tagata Hiromi H Tatebayashi Yoshitaka Y Torrent Carla C Vieta Eduard E Viswanath Biju B Wanchoo Mihir J MJ Zetin Mark M Whybrow Peter C PC

Study Outcome 

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Statistics
Citations : 
Authors :  74
Identifiers
Doi : 10.1016/j.jpsychires.2015.03.013
SSN : 1879-1379
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Age of onset;Bipolar disorder;Hours of daylight;Insolation;Sunlight
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
England