Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).

Journal: AIDS and behavior

Volume: 20

Issue: 7

Year of Publication: 2017

Affiliated Institutions:  J. David Gladstone Institutes, Grant Lab, GIVI, th Floor, Owens Street, San Francisco, , CA, USA. Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA. University of California, San Francisco, CA, USA. Fenway Community Health, Boston, MA, USA. Investigaciones Medicas en Salud, Lima, Peru. School of Public Health, University of Michigan, Ann Arbor, MI, USA. Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa. Fundacion Ecuatoriana Equidad, Guayaquil, Ecuador. University of Sao Paulo Medical School, Sao Paulo, Brazil. National Institutes of Health, Bethesda, MD, USA. J. David Gladstone Institutes, Grant Lab, GIVI, th Floor, Owens Street, San Francisco, , CA, USA. robert.grant@ucsf.edu.

Abstract summary 

We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services.

Authors & Co-authors:  Defechereux Patricia A PA Mehrotra Megha M Liu Albert Y AY McMahan Vanessa M VM Glidden David V DV Mayer Kenneth H KH Vargas Lorena L Amico K Rivet KR Chodacki Piotr P Fernandez Telmo T Avelino-Silva Vivian I VI Burns David D Grant Robert M RM

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Goldney RD, Dal Grande E, Fisher LJ, Wilson D. Population attributable risk of major depression for suicidal ideation in a random and representative community sample. J Affect Disord. 2003;74:267–272. doi: 10.1016/S0165-0327(02)00017-4.
Authors :  14
Identifiers
Doi : 10.1007/s10461-015-1082-2
SSN : 1573-3254
Study Population
Men,Women
Mesh Terms
Adolescent
Other Terms
Depression;FTC/TDF;HIV prevention;Men who have sex with men;PrEP;iPrEx
Study Design
Randomized Control Trial,Longitudinal Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States