ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.
Journal: NeuroImage
Volume: 145
Issue: Pt B
Year of Publication: 2018
Affiliated Institutions:
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey , USA; Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego , CA, USA.
NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo , Norway; NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo , Norway.
Donders Center for Cognitive Neuroscience, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Center, Nijmegen , The Netherlands.
Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA , USA; Dept. of Psychology, University of California, Los Angeles, CA , USA; Brain Research Institute, University of California, Los Angeles, CA , USA.
Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht CX, The Netherlands.
Department of Psychiatry, Massachusetts General Hospital, Boston , USA.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen HB, The Netherlands; Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA , USA.
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin str. , Moscow , Russia.
National Institute of Mental Health Intramural Research Program, Bethesda , USA; Neuroimaging & Cognitive Genomics Centre (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H TK Galway, Ireland.
Institute on Aging, University of Florida, Gainesville, FL , USA.
Department of Psychological Medicine and Psychiatry, Section of Addiction, King's College London, University of London, UK.
Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, La Jolla, CA -, USA.
Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH JZ, UK.
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey , USA.
MRC-SGDP Centre, Institute of Psychiatry, King's College London, London SE AF, UK.
Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, UK; Clinical Neuroscience Studies (CNS) Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA.
Neuroimaging and Cognitive Genomics center (NICOG), School of Psychology, National University of Ireland, Galway, Ireland.
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen XD, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen HB, The Netherlands.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Clinical Neuroscience Studies (CNS) Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA.
Department of Human Genetics, Radboud University Medical Center, Nijmegen , The Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen , The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen HB, The Netherlands.
Department of Statistics, The University of Warwick, Coventry, UK.
Psychiatry Department, University of Vermont, VT, USA.
Department of Psychiatry, Yale University, New Haven, CT , USA; Olin Neuropsychiatric Research Center, Hartford, CT , USA.
Department of Psychiatry, University Medicine Greifswald, Greifswald , Germany; Department of Psychiatry and Psychotherapy, HELIOS Hospital, Stralsund , Germany.
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen XD, The Netherlands; International Max Planck Research School for Language Sciences, Nijmegen XD, The Netherlands.
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan.
Department of Human Genetics, Radboud University Medical Center, Nijmegen , The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen HB, The Netherlands.
Department of Radiology University Medicine Greifswald, Greifswald , Germany.
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD , USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA , USA.
Center for Human Genetic Research, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, USA.
Department of Psychiatry, University of Vermont, Burlington , VT, USA.
QIMR Berghofer Medical Research Institute, Brisbane , Australia.
Groupe d'imagerie Neurofonctionnelle, UMR CNRS CEA Université de Bordeaux, France.
Neuroimaging & Cognitive Genomics Centre (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H TK Galway, Ireland.
Duke Institute for Brain Sciences, Duke University, NC , USA.
Department of Statistics & WMG, University of Warwick, Coventry CV AL, UK; FMRIB Centre, University of Oxford, Oxford OX DU, UK.
Rotman Research Institute, Baycrest, Toronto, ON, Canada; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada; Child Mind Institute, NY, USA.
The Hospital for Sick Children, University of Toronto, Toronto, Canada; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada.
Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Center for Neuroimaging, Dept. of Radiology and Imaging Sciences, Indiana University School of Medicine, W. th Street, Suite , Indianapolis, IN , USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, W. th Street, Suite , Indianapolis, IN , USA.
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WCN BG, UK and Epilepsy Society, Bucks, UK.
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, USA.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Research Unit on Anxiety & Stress Disorders, South Africa.
Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey , USA; Neurogenetics Program, Department of Neurology, UCLA School of Medicine, Los Angeles , USA.
Institut Pasteur, Paris, , France.
Departments of Psychology and Neuroscience, Georgia State University, Atlanta, GA , USA.
Department of Psychiatry and Human Behavior, University of California, Irvine, CA , USA.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen HB, The Netherlands.
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin , Germany.
School of Computing, Informatics and Decision Systems Engineering, Arizona State University, AZ , USA.
Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH XU, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH JZ, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH XU, UK.
Queensland Brain Institute, University of Queensland, Brisbane , Australia.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI , USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI , USA.
Abstract summary
In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others, ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.
Authors & Co-authors:
Thompson Paul M PM
Andreassen Ole A OA
Arias-Vasquez Alejandro A
Bearden Carrie E CE
Boedhoe Premika S PS
Brouwer Rachel M RM
Buckner Randy L RL
Buitelaar Jan K JK
Bulayeva Kazima B KB
Cannon Dara M DM
Cohen Ronald A RA
Conrod Patricia J PJ
Dale Anders M AM
Deary Ian J IJ
Dennis Emily L EL
de Reus Marcel A MA
Desrivieres Sylvane S
Dima Danai D
Donohoe Gary G
Fisher Simon E SE
Fouche Jean-Paul JP
Francks Clyde C
Frangou Sophia S
Franke Barbara B
Ganjgahi Habib H
Garavan Hugh H
Glahn David C DC
Grabe Hans J HJ
Guadalupe Tulio T
Gutman Boris A BA
Hashimoto Ryota R
Hibar Derrek P DP
Holland Dominic D
Hoogman Martine M
Hulshoff Pol Hilleke E HE
Hosten Norbert N
Jahanshad Neda N
Kelly Sinead S
Kochunov Peter P
Kremen William S WS
Lee Phil H PH
Mackey Scott S
Martin Nicholas G NG
Mazoyer Bernard B
McDonald Colm C
Medland Sarah E SE
Morey Rajendra A RA
Nichols Thomas E TE
Paus Tomas T
Pausova Zdenka Z
Schmaal Lianne L
Schumann Gunter G
Shen Li L
Sisodiya Sanjay M SM
Smit Dirk J A DJA
Smoller Jordan W JW
Stein Dan J DJ
Stein Jason L JL
Toro Roberto R
Turner Jessica A JA
van den Heuvel Martijn P MP
van den Heuvel Odile L OL
van Erp Theo G M TGM
van Rooij Daan D
Veltman Dick J DJ
Walter Henrik H
Wang Yalin Y
Wardlaw Joanna M JM
Whelan Christopher D CD
Wright Margaret J MJ
Ye Jieping J
Study Outcome
Source Link: Visit source
Statistics
Citations :
Adams H, the CHARGE and ENIGMA2 Consortia. Adams Dr. Hieab, Hibar Dr. Derrek, Chouraki Dr. Vincent, Stein Dr. Jason, Nyquist Dr. Paul, Renteria Dr. Miguel, Trompet Dr. Stella, Arias-Vasquez Dr. Alejandro, Seshadri Dr. Sudha, Desrivieres Dr. Sylvane, Beecham Dr. Ashley, Jahanshad Dr. Neda, Wittfeld Dr. Katharina, Van der Lee Dr. Sven, Abramovic Ms. Lucija, Alhusaini Dr. Saud, Amin Dr. Najaf, Andersson Dr. Micael, Arfanakis Dr. Konstantinos, Aribisala Dr. Benjamin, Armstrong Dr. Nicola, Athanasiu Lavinia, Axelsson Dr. Tomas, Beiser Dr. Alexa, Bernard Ms. Manon, Bis Dr. Joshua, Blanken Dr. Laura, Blanton Dr. Susan, Bohlken Mr. Marc, Boks Dr. Marco, Bralten Dr. Janita, Brickman Dr. Adam, Carmichael Dr. Owen, Chakravarty Dr. Mallar, Chauhan Dr. Ganesh, Chen Dr. Qiang, Ching Dr. Christopher, Cuellar-Partida Dr. Gabriel, den Braber Dr. Anouk, Trung Doan Dr. Nhat, Ehrlich Dr. Stefan, Filippi Dr. Irina, Ge Tian, Giddaluru Dr. Sudheer, Goldman Dr. Aaron, Gottesman Dr. Rebecca, Greven Dr. Corina, Grimm Dr. Oliver, Griswold Dr. Michael, Guadalupe Dr. Tulio, Hass Johanna, Haukvik Unn, Hilal Dr. Saima, Hofer Dr. Edith, Hoehn Dr. David, Holmes Dr. Avram, Hoogman Dr. Martine, Janowitz Dr. Deborah, Jia Dr. Tianye, Karbalai Dr. Nazanin, Kasperaviciute Dr. Dalia, Kim Dr. Sungeun, Marieke Klein Miss, Kraemer Mr. Bernd, Lee Dr. Phil, Liao Dr. Jiemin, Liewald Mr. David, Lopez Dr. Lorna, Luciano Dr. Michelle, Macare Ms. Christine, Marquand Dr. Andre, Matarin Dr. Mar, Mather Dr. Karen, Mattheisen Manuel, Mazoyer Dr. Bernard, McKay Dr. David, McWhirter Dr. Rebekah, Milaneschi Dr. Yuri, Muetzel Dr. Ryan, Muñoz Maniega Dr. Susana, Nho Dr. Kwangsik, Nugent Dr. Allison, Loohuis Dr. Loes Olde, Oosterlaan Dr. Jaap, Papmeyer Dr. Martina, Pappa Dr. Irene, Pirpamer Dr. Lukas, Pudas Dr. Sara, Pütz Dr. Benno, Rajan Dr. Kumar, Ramasamy Dr. Adaikalavan, Richards Dr. Jennifer, Risacher Dr. Shannon, Roiz-Santiañez Dr. Roberto, Rommelse Dr. Nanda, Rose Dr. Emma, Natalie Royle Miss, Rundek Dr. Tatjana, Sämann Dr. Philipp, Satizabal Dr. Claudia, Schmaal Dr. Lianne, Schork Mr. Andrew, Shen Dr. Li, Shin Dr. Jean, Shumskaya Dr. Elena, Smith Dr. Albert, Sprooten Dr. Emma, Strike Dr. Lachlan, Teumer Dr. Alexander, Thomson Dr. Russell, Tordesillas-Gutierrez Dr. Diana, Toro Mr. Roberto, Trabzuni Dr. Daniah, Vaidya Dr. Dhananjay, Van der Grond Dr. Jeroen, Van der Meer Dr. Dennis, Van Donkelaar Dr. Marjolein, Van Eijk Dr. Kristel, van Erp Dr. Theo, Van Rooij Dr. Daan, Walton Esther, Tjelta Westlye Dr. Lars, Whelan Dr. Christopher, Windham Dr. Beverly, Winkler Dr. Anderson, Woldehawariat Dr. Girma, Wolf Dr. Christiane, Wolfers Dr. Thomas, Xu Dr. Bing, Yanek Dr. Lisa, Yang Dr. Jingyun, Zijdenbos Dr. Alex, Zwiers Dr. Marcel, Agartz Ms. Ingrid, Aggarwal Dr. Neelum, Almasy Dr. Laura, Ames Dr. David, Amouyel Philippe, Andreassen Prof. Ole, Arepalli Dr. Sampath, Assareh Amelia, Barral Dr. Sandra, Bastin Dr. Mark, Becker Dr. James, Becker Dr. Diane, Bennett Dr. David, Blangero Dr. John, Bokhoven Dr. Hans, Boomsma Dr. Dorret, Brodaty Prof. Henry, Brouwer Dr. Rachel, Brunner Prof. Han, Buckner Dr. Randy, Buitelaar Dr. Jan, Bulayeva Dr. Kazima, Cahn Mrs. Wiepke, Calhoun Dr. Vince, Cannon Dara, Cavalleri Dr. Gianpiero, Chen Dr. Christopher, Cheng Dr. Ching-Yu, Cichon Prof. Sven, Cookson Dr. Mark, Corvin Dr. Aiden, Crespo-Facorro Benedicto, Curran Dr. Joanne, Czisch Michael, Dale Dr. Anders, Davies Dr. Gareth, de Geus Prof. Eco, De Jager Dr. Philip, De Zubicaray Dr. Greig, Delanty Dr. Norman, Depondt Dr. Chantal, DeStefano Dr. Anita, Dillman Dr. Allissa, Djurovic Dr. Srdjan, Donohoe Dr. Gary, Drevets Dr. Wayne, Duggirala Dr. Ravi, Dyer Dr. Thomas, Erk Dr. Susanne, Espeseth Dr. Thomas, Evans Dr. Denis, Fedko Dr. Iryna, Fernández Guillén, Ferrucci Dr. Luigi, Fisher Prof. Simon, Fleischman Dr. Debra, Ford Dr. Ian, Foroud Dr. Tatiana, Fox Dr. Peter, Francks Dr. Clyde, Fukunaga Masaki, Gibbs J, Glahn Dr. David, Gollub Dr. Randy, Göring Dr. Harald, Grabe Dr. Hans, Green Dr. Robert, Gruber Dr. Oliver, Guelfi Mr. Manuel, Hansell Dr. 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Uitterlinden André, Valdés Hernández Dr. Maria, Van der Brug Dr. Marcel, van der Lugt Prof. Aad, van der Wee Dr. Nic, van Duijn Prof. Cornelia, van Haren Dr. Neeltje, van 't Ent Dr. Dennis, Van Tol Dr. Marie-Jose, Vardarajan Dr. Badri, Veltman Dr. Dick, Vernooij Dr. Meike, Völzke Dr. Henry, Walter Henrik, Wardlaw Prof. Joanna, Wassink Dr. Thomas, Weale Mike, Weinberger Dr. Daniel, Weiner Prof. Michael, Wen Dr. Wei, Westman Dr. Eric, White Dr. Tonya, Wong Dr. Tien, Wright Dr. Clinton, Dr. Ronal Common genetic variation underlying human intracranial volume highlights developmental influences and continued relevance during late life. 2015 submitted for publication, October 2015.
Authors :
72
Identifiers
Doi :
10.1016/j.neuroimage.2015.11.057
SSN :
1095-9572
Study Population
Male,Female
Mesh Terms
Brain Diseases
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States