The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection.

Journal: Journal of neural transmission (Vienna, Austria : 1996)

Volume: 124

Issue: 4

Year of Publication: 2018

Affiliated Institutions:  Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. , , Wuerzburg, Germany. anne.horn@uniklinik-freiburg.de. Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. , , Wuerzburg, Germany. Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany. Department of Neurology, University Hospital of Duesseldorf, Duesseldorf, Germany. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. IFTZ, Medical University Innsbruck, Innsbruck, Austria. Department of Neurology, University Hospital of Duisburg-Essen, Duisburg-Essen, Germany. Department of Neurology, University Hospital of Muenster, Muenster, Germany. Institute of Mathematics and Informatics, Chair of Mathematics VIII (Statistics), University of Wuerzburg, Wuerzburg, Germany. Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany.

Abstract summary 

We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection). We correlated the polymorphisms with CSF DA levels, HIV dementia score, CD4 T cell counts, and HIV viral load. None of the investigated DA-related polymorphisms was associated with altered CSF DA levels, CD4 T cell count, viral load, and HIV dementia score. The respective allele frequencies were equally distributed between HIV-infected patients and controls. Our findings do not show any influence of the studied genetic polymorphisms on CSF DA levels and HIV infection. This is in contrast to what we found previously for the DAT 3'UTR VNTR and highlights the specific role of the DAT VNTR in HIV infection and disease.

Authors & Co-authors:  Horn Anne A Scheller C C du Plessis S S Burger R R Arendt G G Joska J J Sopper S S Maschke C M CM Obermann M M Husstedt I W IW Hain J J Riederer P P Koutsilieri E E

Study Outcome 

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Statistics
Citations :  Acta Neuropathol. 2001 Feb;101(2):85-91
Authors :  14
Identifiers
Doi : 10.1007/s00702-016-1659-6
SSN : 1435-1463
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Africa;DAT;Dopamine;Dopamine receptors;HIV;Infection;Polymorphisms
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Country of Study
South Africa
Publication Country
Austria