Genetically determined schizophrenia is not associated with impaired glucose homeostasis.

Journal: Schizophrenia research

Volume: 195

Issue: 

Year of Publication: 2018

Affiliated Institutions:  Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA. Electronic address: renato.polimanti@yale.edu. Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

Abstract summary 

Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Mendelian randomization analysis was well-powered, no causal relationship was observed between schizophrenia and T2D, or traits related to glucose impaired homeostasis. Similarly, we did not observe any global genetic overlap among these traits. These findings indicate that there is no causal relationships or shared mechanisms between schizophrenia and impaired glucose homeostasis.

Authors & Co-authors:  Polimanti Renato R Gelernter Joel J Stein Dan J DJ

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–525.
Authors :  3
Identifiers
Doi : 10.1016/j.schres.2017.10.033
SSN : 1573-2509
Study Population
Male,Female
Mesh Terms
Diabetes Mellitus, Type 2
Other Terms
Genetic correlation;Genetics;Mendelian randomization;Metabolic disorders;Psychiatry
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
Netherlands