Preference of Oral Tenofovir Disoproxil Fumarate/Emtricitabine Versus Rectal Tenofovir Reduced-Glycerin 1% Gel Regimens for HIV Prevention Among Cisgender Men and Transgender Women Who Engage in Receptive Anal Intercourse with Men.

Journal: AIDS and behavior

Volume: 21

Issue: 12

Year of Publication: 2018

Affiliated Institutions:  HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute, Columbia University, New York, NY, USA. ac@cumc.columbia.edu. HIV Center for Clinical and Behavioral Studies at New York State Psychiatric Institute, Columbia University, New York, NY, USA. Department of Biostatistics, University of Washington, Seattle, WA, USA. Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA. Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa. Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand. Thailand Ministry of Public Health - U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand. Asociación Civil Impacta Salud y Educación, Lima, Peru. San Francisco Department of Public Health, San Francisco, CA, USA. The Fenway Institute, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA. Department of Obstetrics and Gynecology, University of Puerto Rico School of Medicine, San Juan, PR, USA. School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract summary 

Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens. After trying all three, 28% liked daily oral the least. Gel did not affect sexual enjoyment (88%) or improved it (7-8%). Most partners had no reaction to gel use. Ease of gel use improved significantly between the first and the last few times of daily use. A rectal gel used before and after RAI may constitute an attractive alternative to daily tablet. Experience with product use may increase acceptability.

Authors & Co-authors:  Carballo-Diéguez Alex A Giguere Rebecca R Dolezal Curtis C Leu Cheng-Shiun CS Balán Iván C IC Brown William W Rael Christine C Richardson Barbra A BA Piper Jeanna M JM Bekker Linda-Gail LG Chariyalertsak Suwat S Chitwarakorn Anupong A Gonzales Pedro P Holtz Timothy H TH Liu Albert A Mayer Kenneth H KH Zorrilla Carmen D CD Lama Javier R JR McGowan Ian I Cranston Ross D RD

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Young I, McDaid L. How acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: A review of research on the acceptability of oral pre-exposure prophylaxis and treatment as prevention. AIDS Behav. 2014:195–216.
Authors :  21
Identifiers
Doi : 10.1007/s10461-017-1969-1
SSN : 1573-3254
Study Population
Men,Women
Mesh Terms
Administration, Oral
Other Terms
Acceptability;Gel;Microbicide;PrEP;Rectal
Study Design
Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
United States