Neuroimaging genomics in psychiatry-a translational approach.

Journal: Genome medicine

Volume: 9

Issue: 1

Year of Publication: 2018

Affiliated Institutions:  UCT/MRC Human Genetics Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, . MRC Unit on Risk and Resilience, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, . Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa, . Department of Psychiatry and Mental Health, Groote Schuur Hospital, Cape Town, South Africa, . Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, , USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, , USA. neda.jahanshad@usc.edu.

Abstract summary 

Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early work in neuroimaging genomics focused on mapping the associations of candidate gene variants with neuroimaging measures in small cohorts, the lack of reproducible results inspired better-powered and unbiased large-scale approaches. Notably, genome-wide association studies (GWAS) of brain imaging in thousands of individuals around the world have led to a range of promising findings. Extensions of such approaches are now addressing epigenetics, gene-gene epistasis, and gene-environment interactions, not only in brain structure, but also in brain function. Complementary developments in systems biology might facilitate the translation of findings from basic neuroscience and neuroimaging genomics to clinical practice. Here, we review recent approaches in neuroimaging genomics-we highlight the latest discoveries, discuss advantages and limitations of current approaches, and consider directions by which the field can move forward to shed light on brain disorders.

Authors & Co-authors:  Mufford Mary S MS Stein Dan J DJ Dalvie Shareefa S Groenewold Nynke A NA Thompson Paul M PM Jahanshad Neda N

Study Outcome 

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Citations :  Kovelman I. Neuroimaging methods. In: Hoff E, editor. Research methods in child language: a practical guide. Oxford, UK: Wiley-Blackwell; 2011. pp. 43–59.
Authors :  6
Identifiers
Doi : 102
SSN : 1756-994X
Study Population
Male,Female
Mesh Terms
Animals
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
England