Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.

Journal: Biological psychiatry

Volume: 83

Issue: 3

Year of Publication: 2019

Affiliated Institutions:  National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts; Department of Biomedical Genetics, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia. Imaging Genetics Center, Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California. Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, Durham, North Carolina; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina. National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts. Department of Psychiatry, University of Western Ontario, London, Ontario, Canada. Department of Psychiatry, University of Cape Town, Cape Town, South Africa. Brain Imaging Center, Academic Medical Center, Amsterdam, the Netherlands. Brain Dynamics Centre, Westmead Institute for Medical Research, Sydney, Australia. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; McLean Hospital, Harvard University, Belmont, Massachusetts. Department of Psychology, University of Washington, Seattle, Washington. McLean Hospital, Harvard University, Belmont, Massachusetts. Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands. Clinical Neuroscience Division, VA National Center for PTSD, VA Connecticut HealthCare System, West Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Clinical Neuroscience Division, VA National Center for PTSD, VA Connecticut HealthCare System, West Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut. Department of Psychology, John Jay College of Criminal Justice, City University of New York, New York, New York; Graduate Center, City University of New York, New York, New York. Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Arq National Trauma Center, Diemen, the Netherlands. Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts. Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, North Carolina. Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychological and Brain Sciences, University of Delaware, Newark, Delaware. Department of Psychiatry, University of Toledo, Toledo, Ohio. Department of Psychology, University of New South Wales, Sydney, Australia. Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands. Department of Psychiatry, University of Michigan, Ann Arbor, Michigan. Neuroimaging Brain & Mind Research Institute, University of Sydney, Sydney, Australia. National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, University of Western Ontario, London, Ontario, Canada. Translational Research Center for TBI and Stress Disorders, VA Boston Healthcare System, Boston, Massachusetts; Geriatric Research, Educational and Clinical Center, VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. McLean Hospital, Harvard University, Belmont, Massachusetts; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia. Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, Durham, North Carolina; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina. Electronic address: rajendra.morey@duke.edu.

Abstract summary 

Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group.We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium.In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063).Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Authors & Co-authors:  Logue Mark W MW van Rooij Sanne J H SJH Dennis Emily L EL Davis Sarah L SL Hayes Jasmeet P JP Stevens Jennifer S JS Densmore Maria M Haswell Courtney C CC Ipser Jonathan J Koch Saskia B J SBJ Korgaonkar Mayuresh M Lebois Lauren A M LAM Peverill Matthew M Baker Justin T JT Boedhoe Premika S W PSW Frijling Jessie L JL Gruber Staci A SA Harpaz-Rotem Ilan I Jahanshad Neda N Koopowitz Sheri S Levy Ifat I Nawijn Laura L O'Connor Lauren L Olff Miranda M Salat David H DH Sheridan Margaret A MA Spielberg Jeffrey M JM van Zuiden Mirjam M Winternitz Sherry R SR Wolff Jonathan D JD Wolf Erika J EJ Wang Xin X Wrocklage Kristen K Abdallah Chadi G CG Bryant Richard A RA Geuze Elbert E Jovanovic Tanja T Kaufman Milissa L ML King Anthony P AP Krystal John H JH Lagopoulos Jim J Bennett Maxwell M Lanius Ruth R Liberzon Israel I McGlinchey Regina E RE McLaughlin Katie A KA Milberg William P WP Miller Mark W MW Ressler Kerry J KJ Veltman Dick J DJ Stein Dan J DJ Thomaes Kathleen K Thompson Paul M PM Morey Rajendra A RA

Study Outcome 

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Statistics
Citations :  Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52:1048–1060.
Authors :  54
Identifiers
Doi : 10.1016/j.biopsych.2017.09.006
SSN : 1873-2402
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Amygdala;Childhood trauma;Gender differences;Hippocampus;PTSD;Structural MRI
Study Design
Case Control Trial,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States