Ketamine and rapidly acting antidepressants: Breaking the speed of sound or light?

Journal: The Australian and New Zealand journal of psychiatry

Volume: 52

Issue: 11

Year of Publication: 2019

Affiliated Institutions:  Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, VIC, Australia. School of Psychiatry and Black Dog Institute, University of New South Wales Sydney, Sydney, NSW, Australia. Centre for Youth Mental Health, Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia. Division of Pharmacology, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa.

Abstract summary 

There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.

Authors & Co-authors:  Berk Michael M Loo Collen C Davey Christopher G CG Harvey Brian H BH

Study Outcome 

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Statistics
Citations : 
Authors :  4
Identifiers
Doi : 10.1177/0004867418783567
SSN : 1440-1614
Study Population
Male,Female
Mesh Terms
Antidepressive Agents
Other Terms
Ketamine;antidepressant;depression;psychiatry;treatment
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
England