Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy.
Journal: Behavioural brain research
Volume: 362
Issue:
Year of Publication: 2019
Affiliated Institutions:
Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom, South Africa.
Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Instituto de Investigación e Innovación de SaludIntegral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador; Facultad de Ciencias de la Salud, Universidad Católica "Nuestra Señora de la Asunción", Asunción, Paraguay.
Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, Germany.
Department of Regenerative Medicine, Athersys Inc., Cleveland, OH, USA.
UCL Institute of Women's Health, London, United Kingdom.
Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; UCL Institute of Women's Health, London, United Kingdom; School of Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
Department of Pediatrics, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands; Instituto de Investigación e Innovación de SaludIntegral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador; School of Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands. Electronic address: danilo.gavilanes@mumc.nl.
Abstract summary
There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects of multipotent adult progenitor cells (MAPC) on long-term behavioral outcomes in a preterm rat model of perinatal asphyxia. Rats of both sexes were treated with two doses of MAPCs within 24 h after the insult. Locomotor, cognitive and psychiatric impairments were evaluated starting at 1.5 (juvenile) and 6 months (adult). Hypoxia-ischemia affected locomotion, cognition, and anxiety in a sex-dependent manner, with higher vulnerability observed in males. The MAPC therapy partially attenuated deficits in object recognition memory in females of all tested ages, and in the adult males. The hypoxic insult caused delayed hyperactivity in adult males, which was corrected by MAPC therapy. These results suggest that MAPCs may have long-term benefits for neurodevelopmental outcome after preterm birth and global hypoxia-ischemia, which warrants further preclinical exploration.
Authors & Co-authors:
Barkhuizen Melinda M
van Mechelen Ralph R
Vermeer Marijne M
Chedraui Peter P
Paes Dean D
van den Hove Daniel L A DLA
Vaes Bart B
Mays Robert W RW
Steinbusch Harry W M HWM
Robertson Nicola J NJ
Kramer Boris W BW
Gavilanes Antonio W D AWD
Study Outcome
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