Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites.

Journal: NeuroImage

Volume: 191

Issue: 

Year of Publication: 2019

Affiliated Institutions:  Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: mmikkel@jhmi.edu. Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. Department of Radiology, Haukeland University Hospital, Bergen, Norway. Spinoza Centre for Neuroimaging, Amsterdam, the Netherlands. Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Department of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway. Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium; REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium. Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany. Brain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan. School of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Shandong Medical Imaging Research Institute, Shandong University, Jinan, China. Department of Human Physiology, University of Oregon, Eugene, OR, USA. Department of Radiology, University of Calgary, Calgary, AB, Canada. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany. Academic Unit of Radiology, University of Sheffield, Sheffield, UK. Department of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan. Department of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands. Department of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. GE Healthcare, Calgary, AB, Canada. GE Healthcare, Taipei, Taiwan. New York State Psychiatric Institute, New York, NY, USA. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA; National High Magnetic Field Laboratory, Gainesville, FL, USA. School of Health Sciences, Purdue University, West Lafayette, IN, USA; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA. Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium. Department of Psychiatry, Columbia University, New York, NY, USA. Department of Psychology, University of Washington, Seattle, WA, USA. Center for Mind and Brain, University of California, Davis, Davis, CA, USA. GE Healthcare, Berlin, Germany. Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada. Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Department of Psychology, University of Washington, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA. School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada. Movement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada. Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany. Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.

Abstract summary 

Accurate and reliable quantification of brain metabolites measured in vivo using H magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from differences in the basic approach to quantification, the quantification of metabolite data acquired at different sites and on different platforms poses an additional methodological challenge. In this study, spectrally edited γ-aminobutyric acid (GABA) MRS data were analyzed and GABA levels were quantified relative to an internal tissue water reference. Data from 284 volunteers scanned across 25 research sites were collected using GABA+ (GABA + co-edited macromolecules (MM)) and MM-suppressed GABA editing. The unsuppressed water signal from the volume of interest was acquired for concentration referencing. Whole-brain T-weighted structural images were acquired and segmented to determine gray matter, white matter and cerebrospinal fluid voxel tissue fractions. Water-referenced GABA measurements were fully corrected for tissue-dependent signal relaxation and water visibility effects. The cohort-wide coefficient of variation was 17% for the GABA + data and 29% for the MM-suppressed GABA data. The mean within-site coefficient of variation was 10% for the GABA + data and 19% for the MM-suppressed GABA data. Vendor differences contributed 53% to the total variance in the GABA + data, while the remaining variance was attributed to site- (11%) and participant-level (36%) effects. For the MM-suppressed data, 54% of the variance was attributed to site differences, while the remaining 46% was attributed to participant differences. Results from an exploratory analysis suggested that the vendor differences were related to the unsuppressed water signal acquisition. Discounting the observed vendor-specific effects, water-referenced GABA measurements exhibit similar levels of variance to creatine-referenced GABA measurements. It is concluded that quantification using internal tissue water referencing is a viable and reliable method for the quantification of in vivo GABA levels.

Authors & Co-authors:  Mikkelsen Mark M Rimbault Daniel L DL Barker Peter B PB Bhattacharyya Pallab K PK Brix Maiken K MK Buur Pieter F PF Cecil Kim M KM Chan Kimberly L KL Chen David Y-T DY Craven Alexander R AR Cuypers Koen K Dacko Michael M Duncan Niall W NW Dydak Ulrike U Edmondson David A DA Ende Gabriele G Ersland Lars L Forbes Megan A MA Gao Fei F Greenhouse Ian I Harris Ashley D AD He Naying N Heba Stefanie S Hoggard Nigel N Hsu Tun-Wei TW Jansen Jacobus F A JFA Kangarlu Alayar A Lange Thomas T Lebel R Marc RM Li Yan Y Lin Chien-Yuan E CE Liou Jy-Kang JK Lirng Jiing-Feng JF Liu Feng F Long Joanna R JR Ma Ruoyun R Maes Celine C Moreno-Ortega Marta M Murray Scott O SO Noah Sean S Noeske Ralph R Noseworthy Michael D MD Oeltzschner Georg G Porges Eric C EC Prisciandaro James J JJ Puts Nicolaas A J NAJ Roberts Timothy P L TPL Sack Markus M Sailasuta Napapon N Saleh Muhammad G MG Schallmo Michael-Paul MP Simard Nicholas N Stoffers Diederick D Swinnen Stephan P SP Tegenthoff Martin M Truong Peter P Wang Guangbin G Wilkinson Iain D ID Wittsack Hans-Jörg HJ Woods Adam J AJ Xu Hongmin H Yan Fuhua F Zhang Chencheng C Zipunnikov Vadim V Zöllner Helge J HJ Edden Richard A E RAE

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Alger JR, 2010. Quantitative Proton Magnetic Resonance Spectroscopy and Spectroscopic Imaging of the Brain. Top. Magn. Reson. Imaging 21, 115–128. doi:10.1097/RMR.0b013e31821e568f
Authors :  66
Identifiers
Doi : 10.1016/j.neuroimage.2019.02.059
SSN : 1095-9572
Study Population
Male,Female
Mesh Terms
Adolescent
Other Terms
Editing;GABA;MEGA-PRESS;MRS;Quantification;Tissue correction
Study Design
Exploratory Study,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States