Abstract summary 

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that . (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

Authors & Co-authors:  Ashton Melanie M MM Dean Olivia M OM Walker Adam J AJ Bortolasci Chiara C CC Ng Chee H CH Hopwood Malcolm M Harvey Brian H BH Möller Marisa M McGrath John J JJ Marx Wolfgang W Turner Alyna A Dodd Seetal S Scott James G JG Khoo Jon-Paul JP Walder Ken K Sarris Jerome J Berk Michael M

Study Outcome 

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