Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats.

Journal: Diagnostics (Basel, Switzerland)

Volume: 9

Issue: 3

Year of Publication: 

Affiliated Institutions:  Department of Pediatrics, Maastricht University Medical Centre (MUMC), HX, Maastricht, The Netherlands. m.barkhuizen@maastrichtuniversity.nl. Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, HX, Maastricht, The Netherlands. jsh.vles@mumc.nl. Department of Pediatrics, Maastricht University Medical Centre (MUMC), HX, Maastricht, The Netherlands. r.vanmechelen@maastrichtuniversity.nl. Department of Pediatrics, Maastricht University Medical Centre (MUMC), HX, Maastricht, The Netherlands. marijne.vermeer@gmail.com. Department of Pediatrics, Maastricht University Medical Centre (MUMC), HX, Maastricht, The Netherlands. b.kramer@mumc.nl. Instituto de Investigación e Innovación de Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil , Ecuador. peterchedraui@yahoo.com. Clinical Neurophysiology, Maastricht University Medical Centre, HX Maastricht, The Netherlands. p.bergs@mumc.nl. Clinical Neurophysiology, Maastricht University Medical Centre, HX Maastricht, The Netherlands. v.kranen.mastenbroek@mumc.nl. Department of Pediatrics, Maastricht University Medical Centre (MUMC), HX, Maastricht, The Netherlands. danilo.gavilanes@mumc.nl.

Abstract summary 

Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.

Authors & Co-authors:  Barkhuizen Melinda M Vles Johan S H JSH van Mechelen Ralph R Vermeer Marijne M Kramer Boris W BW Chedraui Peter P Bergs Paul P van Kranen-Mastenbroek Vivianne H J M VHJM Gavilanes Antonio W D AWD

Study Outcome 

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Citations :  Trollmann R., Nüsken E., Wenzel D. Neonatal Somatosensory Evoked Potentials: Maturational Aspects and Prognostic Value. Pediatr. Neurol. 2010;42:427–433. doi: 10.1016/j.pediatrneurol.2009.12.007.
Authors :  9
Identifiers
Doi : 123
SSN : 2075-4418
Study Population
Male
Mesh Terms
Other Terms
cerebral palsy;hypoxia-ischemia;preterm brain;rat model;somatosensory evoked potential
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
Switzerland