Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study.
Journal: Addiction biology
Volume: 25
Issue: 6
Year of Publication: 2021
Affiliated Institutions:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
Departments of Psychiatry, University of Vermont, Burlington, VT, USA.
Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Department of Neurology, Keck School of Medicine, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Department of Psychiatry, University Medical Centre Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Departments of Psychiatry and Neuroscience, Yale University School of Medicine, CT, USA.
Faculty of Health, School of Psychology, Liverpool John Moores University, L AF, Liverpool UK.
Neuroimaging Research Branch, Intramural Research Program, National Institute of Drug Abuse, Baltimore, MD, USA.
Department of Developmental Psychology, University of Amsterdam, The Netherlands.
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Department of Neuroscience & The Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Amsterdam UMC, Department of Psychiatry, Amsterdam Institute for Addiction Research, University of Amsterdam, Amsterdam, The Netherlands.
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Jane and Terry Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, Universityof California at Los Angeles, Los Angeles, CA, USA.
Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Department of Psychiatry and Psychology, Hospital Clinic, IDIBAPS, CIBERSAM, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.
Olin Neuropsychiatry Research Center, Hartford Hospital/IOL, Hartford, CT, USA.
Clinical NeuroImaging Research Core, Division of Intramural Clinical and BiologicalResearch, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, CA, USA.
Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry and Mental Health, Faculty of Health Sciences University of Cape Town, South Africa.
Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Addiction Development and Psychopathology (ADAPT) Lab, University of Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Canada.
Abstract summary
While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.
Authors & Co-authors:
Chye Yann Y
Mackey Scott S
Gutman Boris A BA
Ching Christopher R K CRK
Batalla Albert A
Blaine Sara S
Brooks Samantha S
Caparelli Elisabeth C EC
Cousijn Janna J
Dagher Alain A
Foxe John J JJ
Goudriaan Anna E AE
Hester Robert R
Hutchison Kent K
Jahanshad Neda N
Kaag Anne M AM
Korucuoglu Ozlem O
Li Chiang-Shan R CR
London Edythe D ED
Lorenzetti Valentina V
Luijten Maartje M
Martin-Santos Rocio R
Meda Shashwath A SA
Momenan Reza R
Morales Angelica A
Orr Catherine C
Paulus Martin P MP
Pearlson Godfrey G
Reneman Liesbeth L
Schmaal Lianne L
Sinha Rajita R
Solowij Nadia N
Stein Dan J DJ
Stein Elliot A EA
Tang Deborah D
Uhlmann Anne A
van Holst Ruth R
Veltman Dick J DJ
Verdejo-Garcia Antonio A
Wiers Reinout W RW
Yücel Murat M
Thompson Paul M PM
Conrod Patricia P
Garavan Hugh H
Study Outcome
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