An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
Journal: Human brain mapping
Volume: 43
Issue: 1
Year of Publication: 2022
Affiliated Institutions:
Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Icahn School of Medicine at Mount Sinai, New York, New York.
Keck USC School of Medicine, Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Marina del Rey, California.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Division of Child & Adolescent Psychiatry, UCLA Jane & Terry Semel Institute For Neuroscience, Los Angeles, California.
Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, Toronto, Ontario, Canada.
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Seoul National University Hospital, Seoul, Republic of Korea.
Center for OC and Related Disorders at the New York State Psychiatric Institute and Columbia University Irving Medical Center, New York, New York.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Mathison Centre for Mental Health Research & Education and Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Humboldt-Universität zu Berlin, Department of Psychology, Berlin, Germany.
Department of Psychiatry and Clinical Psychobiology, Scientific Institute Ospedale, Milan, Italy.
Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Department of Psychology, Texas State University, San Marcos, Texas.
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan.
Department of Psychiatry, Yale University, New Haven, Connecticut.
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Research Center for Child Mental Development, Chiba University, Chiba, Japan.
De Bascule, academic center child and adolescent psychiatry, Amsterdam, The Netherlands.
Department of Psychiatry, University of Oxford, Oxford, UK.
Department of Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Department of Child and Adolescent Psychiatry and Psychology, IDIBAPS, CIBERSAM, Department of Medicine, Faculty of Barcelona, Barcelona, Spain.
SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Matieland, South Africa.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.
OCD Research Clinic, Yale University, New Haven, Connecticut.
Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden.
Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo André, Brazil.
Pediatric OCD Consultation Service, Anxiety Treatment and Research Center, McMaster University, Hamilton, Ontario, Canada.
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Anxiety Disorders Center, The Institute of Living, Hartford, Connecticut.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Abstract summary
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.
Authors & Co-authors:
van den Heuvel Odile A OA
Boedhoe Premika S W PSW
Bertolin Sara S
Bruin Willem B WB
Francks Clyde C
Ivanov Iliyan I
Jahanshad Neda N
Kong Xiang-Zhen XZ
Kwon Jun Soo JS
O'Neill Joseph J
Paus Tomas T
Patel Yash Y
Piras Fabrizio F
Schmaal Lianne L
Soriano-Mas Carles C
Spalletta Gianfranco G
van Wingen Guido A GA
Yun Je-Yeon JY
Vriend Chris C
Simpson H Blair HB
van Rooij Daan D
Hoexter Marcelo Q MQ
Hoogman Martine M
Buitelaar Jan K JK
Arnold Paul P
Beucke Jan C JC
Benedetti Francesco F
Bollettini Irene I
Bose Anushree A
Brennan Brian P BP
De Nadai Alessandro S AS
Fitzgerald Kate K
Gruner Patricia P
Grünblatt Edna E
Hirano Yoshiyuki Y
Huyser Chaim C
James Anthony A
Koch Kathrin K
Kvale Gerd G
Lazaro Luisa L
Lochner Christine C
Marsh Rachel R
Mataix-Cols David D
Morgado Pedro P
Nakamae Takashi T
Nakao Tomohiro T
Narayanaswamy Janardhanan C JC
Nurmi Erika E
Pittenger Christopher C
Reddy Y C Janardhan YCJ
Sato João R JR
Soreni Noam N
Stewart S Evelyn SE
Taylor Stephan F SF
Tolin David D
Thomopoulos Sophia I SI
Veltman Dick J DJ
Venkatasubramanian Ganesan G
Walitza Susanne S
Wang Zhen Z
Thompson Paul M PM
Stein Dan J DJ
Study Outcome
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