ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.
Journal: Translational psychiatry
Volume: 10
Issue: 1
Year of Publication: 2021
Affiliated Institutions: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. pthomp@usc.edu. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Department of Psychiatry, University of Münster, Münster, Germany. Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands. Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. Department of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA. Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia. Biometris Wageningen University and Research, Wageningen, The Netherlands. The Center for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland, Galway, Ireland. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. INSERM Unit Team 'Translational Psychiatry', Créteil, France. National Institute of Mental Health, National of Health, Bethesda, MD, USA. Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany. Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, GGZ inGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands. Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. Icahn School of Medicine at Mount Sinai, New York, NY, USA. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Anatomy & Neurosciences, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands. Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. Child & Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA. Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Stanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA, USA. Department of Psychology, University of Bath, Bath, UK. Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. Seoul National University Hospital, Seoul, Republic of Korea. Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, MD, USA. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health & Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychiatry, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands. University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Psychiatry, Pediatrics, and Psychological Sciences, University of Vermont, Burlington, VT, USA. Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK. Provost and Senior Vice President, Western University of Health Sciences, Pomona, CA, USA. Department of Radiology, Loma Linda University Medical Center, Loma Linda, CA, USA. Institute of Psychology, Leiden University, Leiden, The Netherlands. Department of Psychology, Yale University, New Haven, CT, USA. Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC, Australia. Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands. Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, USA. Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, UK. Universite de Montreal, Centre de Recherche CHU Ste-Justine, Montreal, QC, Canada. School of Psychology and Centre for Human Brain Health, University of Birmingham, Birmingham, UK. Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK. Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany. Department of Rehabilitation and Movement Sciences, School of Health Professions, Rutgers Biomedical Health Sciences, Newark, NJ, USA. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Psychiatry, University of Vermont, Burlington, VT, USA. Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA. Turner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. Genentech, Inc., South San Francisco, CA, USA. Department of Psychology, Penn State University, University Park, PA, USA. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Research and Scientific Institute of Pediatrics and Child Health, CCH RAS, Ministry of Science and Higher Education, Moscow, Russian Federation. Department of Pediatrics, Michigan State University, East Lansing, MI, USA. Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, USA. National Center for PTSD at Boston VA Healthcare System, Boston, MA, USA. School of Psychology, University of Auckland, Auckland, New Zealand. Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. Mind Research Network, Albuquerque, NM, USA. Department of Neuroimaging, Institute of Psychology, Psychiatry and Neurosciences, King's College London, London, UK. Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA. Experimental Clinical & Health Psychology, Ghent University, Ghent, Belgium. Radiology and Biomedical Imaging, San Francisco, CA, USA. Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway. Biological Sciences, Purdue University, West Lafayette, IN, USA. National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. Max Planck Institute of Psychiatry, Munich, Germany. Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia. Centre for Population Neuroscience and Precision Medicine (PONS), MRC SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Department of Clinical and Experimental Epilepsy, University College London, London, UK. Department of Psychiatry & Neuroscience Institute, SA MRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa. Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, I. R., Iran. Department of Neurology, TBI and Concussion Center, Salt Lake City, UT, USA. Psychology Department & Neuroscience Institute, Georgia State University, Atlanta, GA, USA. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA. Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. Department of Neurology, University of Utah, Salt Lake City, UT, USA. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Abstract summary
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.Authors & Co-authors: Thompson Paul M PM Jahanshad Neda N Ching Christopher R K CRK Salminen Lauren E LE Thomopoulos Sophia I SI Bright Joanna J Baune Bernhard T BT Bertolín Sara S Bralten Janita J Bruin Willem B WB Bülow Robin R Chen Jian J Chye Yann Y Dannlowski Udo U de Kovel Carolien G F CGF Donohoe Gary G Eyler Lisa T LT Faraone Stephen V SV Favre Pauline P Filippi Courtney A CA Frodl Thomas T Garijo Daniel D Gil Yolanda Y Grabe Hans J HJ Grasby Katrina L KL Hajek Tomas T Han Laura K M LKM Hatton Sean N SN Hilbert Kevin K Ho Tiffany C TC Holleran Laurena L Homuth Georg G Hosten Norbert N Houenou Josselin J Ivanov Iliyan I Jia Tianye T Kelly Sinead S Klein Marieke M Kwon Jun Soo JS Laansma Max A MA Leerssen Jeanne J Lueken Ulrike U Nunes Abraham A Neill Joseph O' JO Opel Nils N Piras Fabrizio F Piras Federica F Postema Merel C MC Pozzi Elena E Shatokhina Natalia N Soriano-Mas Carles C Spalletta Gianfranco G Sun Daqiang D Teumer Alexander A Tilot Amanda K AK Tozzi Leonardo L van der Merwe Celia C Van Someren Eus J W EJW van Wingen Guido A GA Völzke Henry H Walton Esther E Wang Lei L Winkler Anderson M AM Wittfeld Katharina K Wright Margaret J MJ Yun Je-Yeon JY Zhang Guohao G Zhang-James Yanli Y Adhikari Bhim M BM Agartz Ingrid I Aghajani Moji M Aleman André A Althoff Robert R RR Altmann Andre A Andreassen Ole A OA Baron David A DA Bartnik-Olson Brenda L BL Marie Bas-Hoogendam Janna J Baskin-Sommers Arielle R AR Bearden Carrie E CE Berner Laura A LA Boedhoe Premika S W PSW Brouwer Rachel M RM Buitelaar Jan K JK Caeyenberghs Karen K Cecil Charlotte A M CAM Cohen Ronald A RA Cole James H JH Conrod Patricia J PJ De Brito Stephane A SA de Zwarte Sonja M C SMC Dennis Emily L EL Desrivieres Sylvane S Dima Danai D Ehrlich Stefan S Esopenko Carrie C Fairchild Graeme G Fisher Simon E SE Fouche Jean-Paul JP Francks Clyde C Frangou Sophia S Franke Barbara B Garavan Hugh P HP Glahn David C DC Groenewold Nynke A NA Gurholt Tiril P TP Gutman Boris A BA Hahn Tim T Harding Ian H IH Hernaus Dennis D Hibar Derrek P DP Hillary Frank G FG Hoogman Martine M Hulshoff Pol Hilleke E HE Jalbrzikowski Maria M Karkashadze George A GA Klapwijk Eduard T ET Knickmeyer Rebecca C RC Kochunov Peter P Koerte Inga K IK Kong Xiang-Zhen XZ Liew Sook-Lei SL Lin Alexander P AP Logue Mark W MW Luders Eileen E Macciardi Fabio F Mackey Scott S Mayer Andrew R AR McDonald Carrie R CR McMahon Agnes B AB Medland Sarah E SE Modinos Gemma G Morey Rajendra A RA Mueller Sven C SC Mukherjee Pratik P Namazova-Baranova Leyla L Nir Talia M TM Olsen Alexander A Paschou Peristera P Pine Daniel S DS Pizzagalli Fabrizio F Rentería Miguel E ME Rohrer Jonathan D JD Sämann Philipp G PG Schmaal Lianne L Schumann Gunter G Shiroishi Mark S MS Sisodiya Sanjay M SM Smit Dirk J A DJA Sønderby Ida E IE Stein Dan J DJ Stein Jason L JL Tahmasian Masoud M Tate David F DF Turner Jessica A JA van den Heuvel Odile A OA van der Wee Nic J A NJA van der Werf Ysbrand D YD van Erp Theo G M TGM van Haren Neeltje E M NEM van Rooij Daan D van Velzen Laura S LS Veer Ilya M IM Veltman Dick J DJ Villalon-Reina Julio E JE Walter Henrik H Whelan Christopher D CD Wilde Elisabeth A EA Zarei Mojtaba M Zelman Vladimir V
Study Outcome
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Citations : van Erp TGM, et al. Cortical Brain Abnormalities in 4474 Individuals with Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Consortium. Biol. Psychiatry. 2018;84:644–654.Authors : 171
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Doi : 100SSN : 2158-3188