A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study.
Journal: The Australian and New Zealand journal of psychiatry
Volume: 54
Issue: 7
Year of Publication: 2021
Affiliated Institutions:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
D'Or Institute for Research and Education, D'Or São Luiz Network, Rio de Janeiro, Brazil.
Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Psychology, Ryerson University, Toronto, ON, Canada.
RGOc and Department of Psychiatry, Rijksuniversity Groningen, UMC Groningen, Groningen, The Netherlands.
Division of Neurotherapeutics, Massachusetts General Hospital, Boston, MA, USA.
Department of Psychiatry, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Korea.
Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Italy.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Psychology, Fordham University, Bronx, NY, USA.
School of Psychology and Sports Science, Anglia Ruskin University, Cambridge, UK.
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Research Center of the Montreal University Institute of Mental Health, University of Montreal, Montreal, QC, Canada.
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA.
Department of Psychology, University of Waterloo, Waterloo, ON, Canada.
Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Anxiety Disorders Centre, Sunnybrook Health Care Sciences, Toronto, Canada and Department of Psychiatry, University of Toronto, Toronto, Canada.
Inserm U , CNRS UMR , Department of Psychiatry, Institut du Cerveau et de la Moelle, ICM-A-IHU, Sorbonne Université, AP-HP, Paris, France.
Department of Psychiatry and Department of Psychobiology and Methodology of Health Sciences, Bellvitge Biomedical Research Institute-IDIBELL, Mental Health Networking Biomedical Research Centre (CIBERSAM) and Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Psychiatry, Nepean Hospital, Faculty of Medicine and Health, Sydney Medical School, Nepean Clinical School, The University of Sydney, Sydney, NSW, Australia.
Department of Psychiatry and MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
School of Social Work, Boston University, Boston, USA.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TC, USA.
Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada.
Department of Psychiatry and Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
South London and Maudsley NHS Foundation Trust, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA.
Abstract summary
The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders.Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given.Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by ⩾75% of experts as 'primary constructs' and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity).This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.
Authors & Co-authors:
Fontenelle Leonardo F LF
Oldenhof Erin E
Eduarda Moreira-de-Oliveira Maria M
Abramowitz Jonathan S JS
Antony Martin M MM
Cath Danielle D
Carter Adrian A
Dougherty Darin D
Ferrão Ygor A YA
Figee Martijn M
Harrison Ben J BJ
Hoexter Marcelo M
Soo Kwon Jun J
Küelz Anne A
Lazaro Luísa L
Lochner Christine C
Marazziti Donatella D
Mataix-Cols David D
McKay Dean D
Miguel Euripedes C EC
Morein-Zamir Sharon S
Moritz Steffen S
Nestadt Gerald G
O'Connor Kieron K
Pallanti Stefano S
Purdon Christine C
Rauch Scott S
Richter Peggy P
Rotge Jean-Yves JY
Shavitt Roseli G RG
Soriano-Mas Carles C
Starcevic Vladan V
Stein Dan J DJ
Steketee Gail G
Storch Eric A EA
Taylor Steven S
van den Heuvel Odile A OA
Veale David D
Woods Douglas W DW
Verdejo-Garcia Antonio A
Yücel Murat M
Study Outcome
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