ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing.

Journal: Translational psychiatry

Volume: 10

Issue: 1

Year of Publication: 2021

Affiliated Institutions:  Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia. lianne.schmaal@unimelb.edu.au. Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia. Department of Psychology, Stanford University, Stanford, CA, USA. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Department of Psychiatry, University of Münster, Münster, Germany. Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands. Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. FSSBI Scientific Research Institute of Physiology & Basic Medicine, Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia. Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. Department of Psychiatry, Oxford University, Oxford, UK. Institute for Molecular Bioscience, the University of Queensland, Brisbane, QLD, Australia. Department of Psychology, University of Minnesota, Minneapolis, MN, USA. Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia. Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen, Göttingen, Germany. Experimental Therapeutics Branch, NIMH, NIH, Bethesda, MD, USA. Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. School of Psychology, University of East London, London, UK. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany. Illinois Institute of Technology, Chicago, IL, USA. Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia. Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway. Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA. Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany. Sunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia. Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. Psychiatry and Pediatrics, University of Calgary, Addictions and Mental Health Strategic Clinical Network, Calgary, AB, Canada. Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK. Institut d'Investigació Biomèdica-Sant Pau, Barcelona, Spain. Department of Radiology and Nuclear Medicine, location AMC, Amsterdam UMC, Amsterdam, The Netherlands. Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Max Planck Institute of Psychiatry, Munich, Germany. West Region/Institute of Mental Health, Singapore, Singapore. SA MRC Research Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Curium-LUMC, Leiden University Medical Center, Leiden, The Netherlands. Instituto ITACA, Universitat Politècnica de València, Valencia, Spain. Department of Psychiatry and Psychotherapy, Jena, Germany. Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. Department of Psychiatry & Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Section on the Neurobiology and Treatment of Mood Disorders, National Institute of Mental Health, Bethesda, MD, USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.

Abstract summary 

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.

Authors & Co-authors:  Schmaal Lianne L Pozzi Elena E C Ho Tiffany T van Velzen Laura S LS Veer Ilya M IM Opel Nils N Van Someren Eus J W EJW Han Laura K M LKM Aftanas Lybomir L Aleman André A Baune Bernhard T BT Berger Klaus K Blanken Tessa F TF Capitão Liliana L Couvy-Duchesne Baptiste B R Cullen Kathryn K Dannlowski Udo U Davey Christopher C Erwin-Grabner Tracy T Evans Jennifer J Frodl Thomas T Fu Cynthia H Y CHY Godlewska Beata B Gotlib Ian H IH Goya-Maldonado Roberto R Grabe Hans J HJ Groenewold Nynke A NA Grotegerd Dominik D Gruber Oliver O Gutman Boris A BA Hall Geoffrey B GB Harrison Ben J BJ Hatton Sean N SN Hermesdorf Marco M Hickie Ian B IB Hilland Eva E Irungu Benson B Jonassen Rune R Kelly Sinead S Kircher Tilo T Klimes-Dougan Bonnie B Krug Axel A Landrø Nils Inge NI Lagopoulos Jim J Leerssen Jeanne J Li Meng M Linden David E J DEJ MacMaster Frank P FP M McIntosh Andrew A Mehler David M A DMA Nenadić Igor I Penninx Brenda W J H BWJH Portella Maria J MJ Reneman Liesbeth L Rentería Miguel E ME Sacchet Matthew D MD G Sämann Philipp P Schrantee Anouk A Sim Kang K Soares Jair C JC Stein Dan J DJ Tozzi Leonardo L van Der Wee Nic J A NJA van Tol Marie-José MJ Vermeiren Robert R Vives-Gilabert Yolanda Y Walter Henrik H Walter Martin M Whalley Heather C HC Wittfeld Katharina K Whittle Sarah S Wright Margaret J MJ Yang Tony T TT Zarate Carlos C Thomopoulos Sophia I SI Jahanshad Neda N Thompson Paul M PM Veltman Dick J DJ

Study Outcome 

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Statistics
Citations :  World Health Organization. Depression and other common mental disorders: global health estimates. 1–24 (2017).
Authors :  78
Identifiers
Doi : 172
SSN : 2158-3188
Study Population
Male,Female
Mesh Terms
Brain
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States