Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.

Journal: Human brain mapping

Volume: 43

Issue: 1

Year of Publication: 2022

Affiliated Institutions:  National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA. Leiden University Medical Center, Department of Psychiatry, Leiden, The Netherlands. Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Department. of Psychiatry, Amsterdam UMC/VUMC, Amsterdam, The Netherlands. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. Department of Mental Health, University Hospital Parc Taulí-IPT, Barcelona, Spain. Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA. Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA. Department of Psychiatry, New York University, New York, New York, USA. Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA. Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA. Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA. Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, California, USA. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Department of Psychology, Harvard University, Cambridge, Massachusetts, USA. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. Center Of Excellence On Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA. LiNC, Department of Psychiatry, Federal University of São Paulo, São Paulo, São Paulo, Brazil. Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA. Anxiety Disorders Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, Germany. Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Department of Psychiatry & Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Anxiety Disorder Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Centre for Neuroimaging Science, Kings College London, London, UK. School of Psychology, University of Sussex, Brighton, UK. Department of Psychology, Sapienza University of Rome, Rome, Italy. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. Institute of Mental Health, University of Belgrade, Belgrade, Serbia. Graduate Program in Electrical and Computer Engineering, Universidade Tecnológica Federal do Paraná, Curitiba, Puerto Rico, Brazil. Center for Neuromodulation in Depression and Stress, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA. Department of Physics, Stony Brook University, Stony Brook, New York, USA. Department of Psychiatry, The University of Texas at Austin Dell Medical School, Austin, Texas, USA. Laureate Institute for Brain Research, Tulsa, Oklahoma, USA. Department of Psychiatry & Family Medicine and Public Health, University of California, La Jolla, California, USA. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Psychiatry, Washington University, St. Louis, Missouri, USA.

Abstract summary 

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

Authors & Co-authors:  Zugman André A Harrewijn Anita A Cardinale Elise M EM Zwiebel Hannah H Freitag Gabrielle F GF Werwath Katy E KE Bas-Hoogendam Janna M JM Groenewold Nynke A NA Aghajani Moji M Hilbert Kevin K Cardoner Narcis N Porta-Casteràs Daniel D Gosnell Savannah S Salas Ramiro R Blair Karina S KS Blair James R JR Hammoud Mira Z MZ Milad Mohammed M Burkhouse Katie K Phan K Luan KL Schroeder Heidi K HK Strawn Jeffrey R JR Beesdo-Baum Katja K Thomopoulos Sophia I SI Grabe Hans J HJ Van der Auwera Sandra S Wittfeld Katharina K Nielsen Jared A JA Buckner Randy R Smoller Jordan W JW Mwangi Benson B Soares Jair C JC Wu Mon-Ju MJ Zunta-Soares Giovana B GB Jackowski Andrea P AP Pan Pedro M PM Salum Giovanni A GA Assaf Michal M Diefenbach Gretchen J GJ Brambilla Paolo P Maggioni Eleonora E Hofmann David D Straube Thomas T Andreescu Carmen C Berta Rachel R Tamburo Erica E Price Rebecca R Manfro Gisele G GG Critchley Hugo D HD Makovac Elena E Mancini Matteo M Meeten Frances F Ottaviani Cristina C Agosta Federica F Canu Elisa E Cividini Camilla C Filippi Massimo M Kostić Milutin M Munjiza Ana A Filippi Courtney A CA Leibenluft Ellen E Alberton Bianca A V BAV Balderston Nicholas L NL Ernst Monique M Grillon Christian C Mujica-Parodi Lilianne R LR van Nieuwenhuizen Helena H Fonzo Gregory A GA Paulus Martin P MP Stein Murray B MB Gur Raquel E RE Gur Ruben C RC Kaczkurkin Antonia N AN Larsen Bart B Satterthwaite Theodore D TD Harper Jennifer J Myers Michael M Perino Michael T MT Yu Qiongru Q Sylvester Chad M CM Veltman Dick J DJ Lueken Ulrike U Van der Wee Nic J A NJA Stein Dan J DJ Jahanshad Neda N Thompson Paul M PM Pine Daniel S DS Winkler Anderson M AM

Study Outcome 

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Statistics
Citations :  Abramian, D. , & Eklund, A. (2019). Refacing: reconstructing anonymized facial features using GANS. IEEE 16th International Symposium on Biomedical Imaging, Venice, Italy, pp. 1104–1108.
Authors :  88
Identifiers
Doi : 10.1002/hbm.25096
SSN : 1097-0193
Study Population
Male,Female
Mesh Terms
Anxiety Disorders
Other Terms
data sharing;generalized anxiety disorder;mega-analyses;meta-analyses;neuroimaging
Study Design
Case Control Trial,Cross Sectional Study
Study Approach
Country of Study
Publication Country
United States