What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
Journal: Human brain mapping
Volume: 43
Issue: 1
Year of Publication: 2022
Affiliated Institutions: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Genentech, Inc., South San Francisco, California, USA. Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada. Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. Department of Psychiatry, University of California, La Jolla, California, USA. INSERM U, team "Translational Neuro-Psychiatry", Créteil, France. Division of Mental Health and Addicition, Oslo University Hospital, Oslo, Norway. Department of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Department for Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany. Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada. Desert-Pacific MIRECC, VA San Diego Healthcare, San Diego, California, USA. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway. Mood Disorders Unit (GRUDA), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, The Netherlands. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain. Dell Medical School, The University of Texas at Austin, Austin, Texas, USA. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. Milken Institute Center for Strategic Philanthropy, Washington, District of Columbia, USA. Department of Psychiatry and Psychotherapy, Medical Faculty, Technische Universität Dresden, Dresden, Germany. Department of Psychiatry, University of Münster, Münster, Germany. Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA. Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Vita-Salute San Raffaele University, Milan, Italy. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne, Orygen, Melbourne, Victoria, Australia. Department of Psychiatry, University of Oxford, Oxford, UK. Mood Disorders Research Program, Yale School of Medicine, New Haven, Connecticut, USA. Division of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway. MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia. Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia. Department of Psychology, School of Social Sciences and Arts, City, University of London, London, UK. Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway. Center for Neurobehavioral Genetics, Los Angeles, California, USA. Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. Neuroscience Research Australia, Randwick, New South Wales, Australia. Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neurosciences, Paris, France. Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany. Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany. Laboratory of Psychiatric Neuroimaging (LIM-), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Experimental Therapeutics and Molecular Pathophysiology Program, Department of Psychiatry, UTHealth, University of Texas, Houston, Texas, USA. Hurvitz Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada. School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia. University of Cincinnati, Cincinnati, Ohio, USA. MEG Core Facility, Bethesda, Maryland, USA. UCLA Center for Neurobehavioral Genetics, Los Angeles, California, USA. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Research Group, Instituto de Alta Tecnología Médica (IATM), Medellín, Colombia. University of Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France. Department of Psychiatry, Amsterdam UMC, location AMC, Amsterdam, The Netherlands. Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. West Region, Institute of Mental Health, Singapore, Singapore. Center of Excellent on Mood Disorders, UTHealth Houston, Houston, Texas, USA. Papanikolaou General Hospital, Thessaloniki, Greece. Department of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands. Department of Neuropsychology and Clinical Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany. Department of Psychology, University of Oslo, Oslo, Norway. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Department of Psychiatry and Behavioral Sciences, UTHealth Houston, Houston, Texas, USA. Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. Chief Experimental Therapeutics & Pathophysiology Branch, Bethesda, Maryland, USA.
Abstract summary
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.Authors & Co-authors: Ching Christopher R K CRK Hibar Derrek P DP Gurholt Tiril P TP Nunes Abraham A Thomopoulos Sophia I SI Abé Christoph C Agartz Ingrid I Brouwer Rachel M RM Cannon Dara M DM de Zwarte Sonja M C SMC Eyler Lisa T LT Favre Pauline P Hajek Tomas T Haukvik Unn K UK Houenou Josselin J Landén Mikael M Lett Tristram A TA McDonald Colm C Nabulsi Leila L Patel Yash Y Pauling Melissa E ME Paus Tomas T Radua Joaquim J Soeiro-de-Souza Marcio G MG Tronchin Giulia G van Haren Neeltje E M NEM Vieta Eduard E Walter Henrik H Zeng Ling-Li LL Alda Martin M Almeida Jorge J Alnaes Dag D Alonso-Lana Silvia S Altimus Cara C Bauer Michael M Baune Bernhard T BT Bearden Carrie E CE Bellani Marcella M Benedetti Francesco F Berk Michael M Bilderbeck Amy C AC Blumberg Hilary P HP Bøen Erlend E Bollettini Irene I Del Mar Bonnin Caterina C Brambilla Paolo P Canales-Rodríguez Erick J EJ Caseras Xavier X Dandash Orwa O Dannlowski Udo U Delvecchio Giuseppe G Díaz-Zuluaga Ana M AM Dima Danai D Duchesnay Édouard É Elvsåshagen Torbjørn T Fears Scott C SC Frangou Sophia S Fullerton Janice M JM Glahn David C DC Goikolea Jose M JM Green Melissa J MJ Grotegerd Dominik D Gruber Oliver O Haarman Bartholomeus C M BCM Henry Chantal C Howells Fleur M FM Ives-Deliperi Victoria V Jansen Andreas A Kircher Tilo T J TTJ Knöchel Christian C Kramer Bernd B Lafer Beny B López-Jaramillo Carlos C Machado-Vieira Rodrigo R MacIntosh Bradley J BJ Melloni Elisa M T EMT Mitchell Philip B PB Nenadic Igor I Nery Fabiano F Nugent Allison C AC Oertel Viola V Ophoff Roel A RA Ota Miho M Overs Bronwyn J BJ Pham Daniel L DL Phillips Mary L ML Pineda-Zapata Julian A JA Poletti Sara S Polosan Mircea M Pomarol-Clotet Edith E Pouchon Arnaud A Quidé Yann Y Rive Maria M MM Roberts Gloria G Ruhe Henricus G HG Salvador Raymond R Sarró Salvador S Satterthwaite Theodore D TD Schene Aart H AH Sim Kang K Soares Jair C JC Stäblein Michael M Stein Dan J DJ Tamnes Christian K CK Thomaidis Georgios V GV Upegui Cristian Vargas CV Veltman Dick J DJ Wessa Michèle M Westlye Lars T LT Whalley Heather C HC Wolf Daniel H DH Wu Mon-Ju MJ Yatham Lakshmi N LN Zarate Carlos A CA Thompson Paul M PM Andreassen Ole A OA
Study Outcome
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Statistics
Citations : Abe, C. , Ekman, C. J. , Sellgren, C. , Petrovic, P. , Ingvar, M. , & Landen, M. (2015). Manic episodes are related to changes in frontal cortex: A longitudinal neuroimaging study of bipolar disorder 1. Brain, 138(Pt 11), 3440–3448. 10.1093/brain/awv266Authors : 117
Identifiers
Doi : 10.1002/hbm.25098SSN : 1097-0193